|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
|
24836286 |
2014 |
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASDB |
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
|
24836286 |
2014 |
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The genotypes of rs6983267 in peripheral blood and primary cancers, MYC activity and copy number (CN) alteration were examined in 107 CRCs.
|
24390711 |
2014 |
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Here, we report that CCAT2, a novel long noncoding RNA transcript (lncRNA) encompassing the rs6983267 SNP, is highly overexpressed in microsatellite-stable colorectal cancer and promotes tumor growth, metastasis, and chromosomal instability.
|
23796952 |
2013 |
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The presence of the minor allele of rs6983267 at 8q24.21 worsened the prognosis of CRC through up-regulation of MYC transcription.
|
22976378 |
2013 |
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
|
23266556 |
2013 |
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASDB |
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
|
23266556 |
2013 |
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A lower risk of CRC was associated with regular aspirin use and the T allele of rs6983267.
|
24317174 |
2013 |
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In our previous work, we showed that the colorectal cancer (CRC) risk variant rs6983267 at 8q24 resides within a TCF4 binding site at the MYC-335 enhancer, with the risk allele G having a stronger binding capacity and Wnt responsiveness.
|
22429595 |
2012 |
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
We used meta-analysis of an efficient empirical-Bayes estimator to detect potential multiplicative interactions between each of the SNPs [rs16892766 at 8q23.3 (EIF3H/UTP23), rs6983267 at 8q24 (MYC), rs10795668 at 10p14 (FLJ3802842), rs3802842 at 11q23 (LOC120376), rs4444235 at 14q22.2 (BMP4), rs4779584 at 15q13 (GREM1), rs9929218 at 16q22.1 (CDH1), rs4939827 at 18q21 (SMAD7), rs10411210 at 19q13.1 (RHPN2), and rs961253 at 20p12.3 (BMP2)] and select major CRC risk factors (sex, body mass index, height, smoking status, aspirin/nonsteroidal anti-inflammatory drug use, alcohol use, and dietary intake of calcium, folate, red meat, processed meat, vegetables, fruit, and fiber).
|
22367214 |
2012 |
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Only iSNP rs6983267 at 8q24.21 and sSNPs rs6695584, rs11986063, rs3087967, rs2059254, and rs7226855 at 1q41, 8q23.3, 11q23.1, 16q22.1 and 18q21.1 respectively showed evidence of association with CRC risk, with odds ratios (OR) ranging from 1.13 to 1.40. sSNP rs827401 at 10p14 was associated with rectal cancer risk (OR = 0.74, 95% CI 0.63-0.88) but not disease prognosis (OR = 0.91, 95% CI 0.69-1.20).
|
22879968 |
2012 |
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
There is a robust risk of the minor G allele at the 8q24 rs6983267 SNP; however, a major T allele SNP could more clearly reveal a correlation with CRC specifically when DM is present.
|
22434246 |
2012 |
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In conclusion, our findings suggest that the 8q24 rs6983267 SNP may play a pivotal role in the development of sporadic CRC in Iranian population.
|
21567271 |
2012 |
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
On the other hand, the carcinogenic significance of the single nucleotide polymorphism (SNP), rs6983267 at 8q24, in CRC has been reported.
|
22486879 |
2012 |
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In particular, the 8q24 single nucleotide polymorphism (SNP), rs6983267, has reproducibly been associated with the risk of developing CRC.
|
22848671 |
2012 |
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our data suggested that the rs6983267 G > T polymorphism is a risk factor for CRC in Asians, Europeans, and Americans with European ancestry.
|
21722176 |
2011 |
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found no significant differences between the association of rs6983267 and colorectal cancer and colorectal adenomas.
|
21455501 |
2011 |
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Moreover, we found cumulative effects of three genetic factors (rs7758229, rs6983267, and rs4939827 in SMAD7) and one environmental factor (alcohol drinking) which appear to increase CRC risk approximately twofold.
|
21242260 |
2011 |
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASDB |
Moreover, we found cumulative effects of three genetic factors (rs7758229, rs6983267, and rs4939827 in SMAD7) and one environmental factor (alcohol drinking) which appear to increase CRC risk approximately twofold.
|
21242260 |
2011 |
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
We studied the generalizability of the associations with 11 risk variants for CRC on 8q23 (rs16892766), 8q24 (rs6983267), 9p24 (rs719725), 10p14 (rs10795668), 11q23 (rs3802842), 14q22 (rs4444235), 15q13 (rs4779584), 16q22 (rs9929218), 18q21 (rs4939827), 19q13 (rs10411210), and 20p12 (rs961253) in a multiethnic sample of 2,472 CRC cases, 839 adenoma cases and 4,466 controls comprised of European American, African American, Native Hawaiian, Japanese American, and Latino men and women.
|
21071539 |
2011 |
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Moreover, we found cumulative effects of three genetic factors (rs7758229, rs6983267, and rs4939827 in SMAD7) and one environmental factor (alcohol drinking) which appear to increase CRC risk approximately twofold.
|
21242260 |
2011 |
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Among African Americans, the SNP rs6983267 at 8q24.21 was not associated with CRC (odds ratio, 1.18; P = .12); instead, the 8q24.21 SNP rs7014346 (odds ratio, 1.15; P = .03) was associated with CRC in this population.
|
20659471 |
2010 |
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs6983267 in region 3, previously implicated in CRC risk, trended toward association with disease in European Americans but not in African Americans.
|
19520795 |
2009 |
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer.
|
19561607 |
2009 |
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The polymorphism rs6983267 showed a significant association with CRC in a Japanese population.
|
19857256 |
2009 |