|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, since NRG1 rs6994992 is not a schizophrenia risk variant in the Han Chinese population, the validated association suggested that ethnic difference may exist in the relationship between NRG1 rs6994992, schizophrenia and creativity.
|
31649580 |
2019 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A functional polymorphism (SNP8NRG243177/rs6994992; C/T) in the promoter region of the brain-specific type IV neuregulin-1 gene ( NRG1) has been associated with psychiatric disorders (e.g. schizophrenia and bipolar disorder) that often present higher odds of smoking, alcohol and illicit drug use.
|
27353026 |
2017 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine the genetic association between qualitative and quantitative traits of autism spectrum disorder (ASD) and neuregulin 1 (NRG1)-a schizophrenia candidate gene-we examined six single nucleotide polymorphisms (SNPs) in NRG1 using a family-based association test (FBAT) in Korean families with ASD. rs35753505 and rs6994992 SNPs in NRG1 revealed a statistically significant family-based association with three quantitative traits for sociality.
|
25858800 |
2015 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygosity for the schizophrenia risk allele (T) of rs6994992 conferred lower cortical NRG1-IVNV levels.
|
24935406 |
2014 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Schizophrenia-risk variant rs6994992 in the neuregulin-1 gene on brain developmental trajectories in typically developing children.
|
24865593 |
2014 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Three variants and one microsatellite showed allelic association with SZ (rs35753505, rs4733263, rs6994992, and microsatellite 420M9-1395, p≤0.05 uncorrected for multiple comparisons).
|
23360725 |
2013 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The objective of this cross-sectional genetic association study was to determine the relationship of six core single-nucleotide polymorphisms within the NRG1 gene identified as promising schizophrenia risk genes (rs6994992, SNP8NRG221132, SNP8NRG241930, rs3924999, rs2439272 and rs10503929) to prepulse inhibition (PPI) of the acoustic startle reflex, a well validated schizophrenia endophenotype.
|
21035784 |
2011 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, taking into account the rs6994992 SNP in the NRG1 gene, which was also associated with LV volume in a previous study, the DISC1 SNP only predicted LV enlargement among those patients carrying the T allele in the NRG1 SNP.
|
19913623 |
2010 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A polymorphism of the neuregulin 1 gene (SNP8NRG243177/rs6994992) affects reactivity to expressed emotion in schizophrenia.
|
18543275 |
2009 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We were unable to replicate previous associations of rs6994992 with schizophrenia and, moreover, did not find significant associations with age of onset, an estimate of pre-morbid IQ, or neurocognition.
|
18286587 |
2008 |
|
Major Depressive Disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
We investigated the separate effects of and possible interactions between the functional polymorphisms of brain-derived neurotrophic factor (BDNF) rs11030101, BDNF rs61888800, and neuregulin-1 (NRG1) rs3924999 and NRG1 rs6994992 on change of temperament scores in a clinical sample of subjects with major depression (MDD), who received selective serotonin reuptake inhibitor treatment for a period of 6 weeks.
|
29310728 |
2018 |
|
Bipolar Disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
A functional polymorphism (SNP8NRG243177/rs6994992; C/T) in the promoter region of the brain-specific type IV neuregulin-1 gene ( NRG1) has been associated with psychiatric disorders (e.g. schizophrenia and bipolar disorder) that often present higher odds of smoking, alcohol and illicit drug use.
|
27353026 |
2017 |
|
Major Depressive Disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
We observed however an association of rs6994992 with NRG1 type IV expression in DLPFC and a significantly decreased expression in MDD compared to controls.
|
21745728 |
2011 |
|
Bipolar Disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
We tested four single nucleotide polymorphisms (SNPs), SNP8NRG221533 (rs35753505), SNP8NRG241930, SNP8NRG243177 (rs6994992) and SNPNRG222662 (rs4623364) for allelic and haplotypic association with bipolar disorder and the presence of psychotic or mood-incongruent psychotic features.
|
19339916 |
2009 |
|
Nonorganic psychosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism of the neuregulin 1 gene (SNP8NRG243177/rs6994992) increases the risk of psychosis, affects prefrontal activation and structural connectivity in the brain, and is related to the expression of a specific neuregulin 1 isoform.
|
18543275 |
2009 |
|
Psychotic Disorders
|
|
0.020 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism of the neuregulin 1 gene (SNP8NRG243177/rs6994992) increases the risk of psychosis, affects prefrontal activation and structural connectivity in the brain, and is related to the expression of a specific neuregulin 1 isoform.
|
18543275 |
2009 |
|
Nonorganic psychosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The neuregulin 1 (NRG1) promoter single nucleotide polymorphism (SNP) rs6994992 has shown association with decreased activation of frontal and temporal lobe regions, increased risk of psychosis, and decreased premorbid IQ.
|
18286587 |
2008 |
|
Psychotic Disorders
|
|
0.020 |
GeneticVariation
|
BEFREE |
The neuregulin 1 (NRG1) promoter single nucleotide polymorphism (SNP) rs6994992 has shown association with decreased activation of frontal and temporal lobe regions, increased risk of psychosis, and decreased premorbid IQ.
|
18286587 |
2008 |
|
Mental disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
A functional polymorphism (SNP8NRG243177/rs6994992; C/T) in the promoter region of the brain-specific type IV neuregulin-1 gene ( NRG1) has been associated with psychiatric disorders (e.g. schizophrenia and bipolar disorder) that often present higher odds of smoking, alcohol and illicit drug use.
|
27353026 |
2017 |
|
Abnormal behavior
|
|
0.010 |
GeneticVariation
|
BEFREE |
A functional polymorphism (SNP8NRG243177/rs6994992; C/T) in the promoter region of the brain-specific type IV neuregulin-1 gene ( NRG1) has been associated with psychiatric disorders (e.g. schizophrenia and bipolar disorder) that often present higher odds of smoking, alcohol and illicit drug use.
|
27353026 |
2017 |
|
Autism Spectrum Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
To determine the genetic association between qualitative and quantitative traits of autism spectrum disorder (ASD) and neuregulin 1 (NRG1)-a schizophrenia candidate gene-we examined six single nucleotide polymorphisms (SNPs) in NRG1 using a family-based association test (FBAT) in Korean families with ASD. rs35753505 and rs6994992 SNPs in NRG1 revealed a statistically significant family-based association with three quantitative traits for sociality.
|
25858800 |
2015 |
|
Multiple Sclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Totally, our results showed no significant difference in the allelic and genotype frequencies of these two NRG1 polymorphisms between MS patients and control group in Iranian population; but statistically significant association was found for the progressive forms of MS (secondary progressive-MS and primary progressive-MS) for functional SNP of rs6994992 polymorphism.
|
25802071 |
2015 |
|
Psychotic symptom
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, NRG1 rs6994992 genotype moderated the curvilinear association between depression symptom severity and psychotic symptom patterns.
|
24123921 |
2014 |
|
Depressive Symptoms
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, NRG1 rs6994992 genotype moderated the curvilinear association between depression symptom severity and psychotic symptom patterns.
|
24123921 |
2014 |
|
Expressed Emotion
|
|
0.010 |
GeneticVariation
|
BEFREE |
A polymorphism of the neuregulin 1 gene (SNP8NRG243177/rs6994992) affects reactivity to expressed emotion in schizophrenia.
|
18543275 |
2009 |