|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
SNP rs738409 in the adiponutrin gene (PNPLA3) is a well described factor for steatosis.
|
23870067 |
2014 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Stepwise logistic regression analysis revealed that the strongest factor independently associated with steatosis was the carriage of the PNPLA3 rs738409 GG genotype (odds ratio [OR]/95% confidence intervals [CI]:2.34/1.557-3.515, P < 0.001).
|
26139292 |
2015 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The steatosis grade was not associated with rs738409.
|
21176169 |
2010 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs738409 SNP in PNPLA3 is associated with an increased risk of steatosis in patients infected with HCV genotypes non-3.
|
21236304 |
2011 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs738409 PNPLA3 genotype influences steatosis development in CHC and is independently associated with cirrhosis and other steatosis-related clinical outcomes, such as lack of response to antiviral treatment and possibly HCC.
|
21319195 |
2011 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs738409 GG genotype was associated with advanced fibrosis and steatosis, but not with HOMA-IR.
|
22634340 |
2012 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The I148M (rs738409) genetic variant of patatin-like phospholipase domain-containing 3 gene (PNPLA3) is known to modulate hepatic triglyceride accumulation, leading to steatosis.
|
22724004 |
2012 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The I148M PNPLA3 polymorphism influences serum adiponectin in patients with fatty liver and healthy controls.
|
22898488 |
2012 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs738409 genetic variant in the patatin-like phospholipase domain-containing 3 (PNPLA3, adiponutrin) gene has been implicated as a genetic determinant of the entire spectrum of liver diseases, ranging from steatosis, chronic hepatitis, cirrhosis and ultimately to HCC.
|
23333103 |
2013 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs738409 polymorphism was only significantly associated with risk of simple steatosis in the allele contrast and had no effect in the other genetic models.
|
25791171 |
2015 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The I148M variant has a strong impact on the full spectrum of liver damage related to fatty liver, encompassing non-alcoholic steatohepatitis, advanced fibrosis, and hepatocellular carcinoma, and influences the response to therapeutic approaches.
|
26409295 |
2016 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The p.I148M variant leads to macrovescicular steaosis and predisposes to liver disorders from steatohepatitis to fibrosis.
|
30308089 |
2018 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The amount of abdominal fat can increase the association of PNPLA3 p.I148M with liver steatosis.
|
23808989 |
2013 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association of PNPLA3 p.I148M with liver steatosis increased with the greater amount of abdominal fat, irrespective of BMI.
|
25986529 |
2015 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association of the PNPLA3 I148M protein variant (p.I148M) with steatosis, fibrosis stage, and cirrhosis was evaluated by logistic regression analysis.
|
22719190 |
2012 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The G allele of rs738409 (PNPLA3) and the T allele of rs780094 (GCKR) were associated with HS with a high level of ALT (odds ratio [OR], 1.36; P = .01; and OR, 1.30; P = .03, respectively).
|
23416328 |
2013 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The G-allele of PNPLA3 rs738409 was associated with NAFLD (odds ratio [OR] 1.55, 95% confidence interval 1.13-2.11, P = 0.006) and moderate-to-severe steatosis (OR 3.77, 95% confidence interval 1.78-7.98, P = 0.001) adjusted for age, sex, and BMI standard deviation score.
|
25522307 |
2015 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The genetic polymorphism I148M of the patatin-like phospholipase domain-containing 3 (PNPLA3) is associated with hepatic steatosis and its progression to steatohepatitis (NASH), fibrosis and cancer.
|
29116096 |
2017 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The genetic polymorphism with an isoleucine-to-methionine substitution at position 148 (rs738409 C>G) in the patatin-like phospholipase domain protein 3 (PNPLA3) gene confers risk of steatosis.
|
25964223 |
2015 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Impact of PNPLA3 rs738409 SNP on Liver Fibrosis Progression, Portal Hypertension and Hepatic Steatosis in HIV/HCV Coinfection.
|
26599080 |
2015 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The influence of recipient and donor TM6SF2 genotypes, PNPLA3 rs738409 genotypes and nongenetic factors on the steatosis grade assessed 6 - 30 months after transplantation was analyzed by ordinal logistic regression.
|
31356578 |
2020 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 C > G single nucleotide polymorphism (SNP) has been associated with steatosis and fibrosis in previous NAFLD populations in which cirrhotic patients were very poorly represented.
|
27150500 |
2016 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The PNPLA3 (rs738409 C>G) polymorphism favors steatosis and fibrosis progression in CHC.
|
21488075 |
2011 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The PNPLA3 rs738409 polymorphism is associated with steatosis severity, hepatocellular ballooning, lobular inflammation, and perivenular fibrosis in pediatric NAFLD.
|
20648474 |
2010 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The PNPLA3 I148M variant is associated with the ultrasonography-determined steatosis degree in Chinese population.
|
23176674 |
2012 |