|
Kidney Failure, Chronic
|
|
0.720 |
GeneticVariation
|
GWASCAT |
Several variants at the <i>APOL1</i> locus were associated with ESKD including the <i>APOL1</i> G1 rs73885319 (<i>p</i> = 1.2 × 10<sup>-9</sup>).
|
31178898 |
2019 |
|
Kidney Failure, Chronic
|
|
0.720 |
GeneticVariation
|
BEFREE |
Several variants at the <i>APOL1</i> locus were associated with ESKD including the <i>APOL1</i> G1 rs73885319 (<i>p</i> = 1.2 × 10<sup>-9</sup>).
|
31178898 |
2019 |
|
Kidney Failure, Chronic
|
|
0.720 |
GeneticVariation
|
BEFREE |
We use recently released sequences from the 1000 Genomes Project to identify two western African-specific missense mutations (S342G and I384M) in the neighboring APOL1 gene, and demonstrate that these are more strongly associated with ESKD than previously reported MYH9 variants.
|
20635188 |
2010 |
|
FOCAL SEGMENTAL GLOMERULOSCLEROSIS 4, SUSCEPTIBILITY TO
|
|
0.700 |
GeneticVariation
|
UNIPROT |
APOL1 risk variants, race, and progression of chronic kidney disease.
|
24206458 |
2013 |
|
Chronic kidney disease stage 5
|
|
0.020 |
GeneticVariation
|
BEFREE |
Several variants at the <i>APOL1</i> locus were associated with ESKD including the <i>APOL1</i> G1 rs73885319 (<i>p</i> = 1.2 × 10<sup>-9</sup>).
|
31178898 |
2019 |
|
Chronic Kidney Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
Two SNPs (rs73885319, rs60910145) and haplotypes (G-A-G; G1; G2) of the apolipoprotein L1 (APOL1) gene were studied in more than one population group, with similar association with prevalent CKD observed.
|
30340464 |
2018 |
|
Chronic Kidney Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
Notably, two APOL1 alleles, termed G1 [c.(1072A>G; 1200T>G)] and G2 (c.1212_1217del6), are strongly associated with higher rates of nondiabetic CKD and an increased risk for hypertensive end-stage renal disease.
|
26773863 |
2016 |
|
Chronic kidney disease stage 5
|
|
0.020 |
GeneticVariation
|
BEFREE |
We use recently released sequences from the 1000 Genomes Project to identify two western African-specific missense mutations (S342G and I384M) in the neighboring APOL1 gene, and demonstrate that these are more strongly associated with ESKD than previously reported MYH9 variants.
|
20635188 |
2010 |
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
Apolipoprotein L1 (APOL1) rs73885319 (OR = 1.52; CI: 1.09-2.13, P-value = .013), rs2383207 in CDKN2A/CDKN2B (OR = 3.08; CI: 1.15-8.26, P -value = .026) and rs2107595 (OR = 1.70; CI: 1.12-2.60, P-value = .014) and rs28688791 (OR = 1.52; CI: 1.03-2.26, P-value = .036) in HDAC9 gene were associated with SVD stroke at 0.05 significance level.
|
28975602 |
2018 |
|
End stage renal disease due to hypertension
|
|
0.010 |
GeneticVariation
|
BEFREE |
Notably, two APOL1 alleles, termed G1 [c.(1072A>G; 1200T>G)] and G2 (c.1212_1217del6), are strongly associated with higher rates of nondiabetic CKD and an increased risk for hypertensive end-stage renal disease.
|
26773863 |
2016 |