|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between brain-derived neurotrophic factor genetic polymorphism Val66Met and susceptibility to bipolar disorder: a meta-analysis.
|
25539739 |
2014 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We performed a family-based association study and ETDT analyses of the Val66Met polymorphism in 312 BD nuclear families, and compared allele-specific mRNA levels in both post-mortem brain samples and B lymphoblasts from BD patients and controls.
|
18606495 |
2008 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Val66Met polymorphism of the BDNF gene may be associated with cognitive performance on the WCST in bipolar mood disorder but not in schizophrenia.
|
16472361 |
2006 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Few genetic studies exploring the impact of Val66Met on cognition in BD.
|
30078664 |
2019 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here we investigated a two hit gene environment model in relation to functional genomic factors (BDNF mRNA), and volume of hippocampal subfields in schizophrenia spectrum and bipolar disorders, focusing on both an environmental (childhood trauma) and genetic risk factor (BDNF val66met).
|
25246365 |
2014 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analysis reveals no association of the Val66Met polymorphism of brain-derived neurotrophic factor with either schizophrenia or bipolar disorder.
|
17417060 |
2007 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF val66met polymorphism is a potential vulnerability factor for cognitive impairment in BD.
|
24862657 |
2014 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Sixty-six subjects with BD (41 in manic and 25 in depressive episodes) and 78 healthy volunteers were genotyped for BDNF Val(66)Met and tested for creativity using the Barrow Welsh Art Scale (BWAS) and neuropsychological tests.
|
22484201 |
2012 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that BDNF G196A as well as 5HTT-LPR polymorphisms confer risk for SB in BD, but we did not observe any evidence for an interaction between them.
|
18657242 |
2008 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Previous studies have suggested that the Val66Met (also known as rs6265 or G196A) variant of BDNF is associated with bipolar disorder (BPD), but the results have been inconclusive.
|
19330778 |
2010 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although the Val66Met polymorphism at the BDNF gene does not seem to play a significant role in children and adolescents with BD or ADHD, BDNF serum levels deserve further attention in future research on neurobiological aspects of BD and ADHD.
|
27209073 |
2016 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further studies are needed to evaluate the genetic association between the val66met allele and the BD-PTSD population, along with central/peripheral BDNF levels and epigenetic patterns of BDNF gene regulation within these patients.
|
21931317 |
2012 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia.
|
24468644 |
2014 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study suggests that the markers examined thus far in COMT and SLC6A4 are not associated with pediatric bipolar disorder and that if the val66met marker in BDNF is associated with pediatric bipolar disorder the magnitude of the association is much smaller than first reported.
|
19193231 |
2009 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The val66met single-nucleotide polymorphism (SNP) showed significant (P = 0.005) association for valine (allele G) with schizophrenia but not bipolar disorder.
|
15630410 |
2005 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the neurochemistry of the left dorsolateral prefrontal cortex of bipolar disorder and healthy participants in relation to the brain-derived neurotrophic factor val66met polymorphism using H-magnetic resonance spectroscopy.
|
17885603 |
2007 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism with early-onset bipolar disorder.
|
26528762 |
2015 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Val66Met polymorphism of the BDNF gene is unrelated to the development or clinical features of bipolar disorder, at least in a Japanese population.
|
15336520 |
2004 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Lithium response and Val66Met polymorphism of the brain-derived neurotrophic factor gene in Japanese patients with bipolar disorder.
|
16538178 |
2006 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach.Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers.
|
28479278 |
2017 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of the present study was to examine the interplay between the BDNF Val(66)Met polymorphism and stressful life events (SLEs) in bipolar disorder.
|
20172611 |
2010 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Variation at the Val66Met polymorphism of BDNF does not play a major role in influencing susceptibility to bipolar disorder as a whole, but is associated with susceptibility to the rapid-cycling subset of the disorder.
|
16388065 |
2006 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although the present study has some limitations, the results indicate a lack of association between the Val66Met polymorphism and bipolar disorder</span>.
|
25041243 |
2015 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We aimed to explore whether anxiety in BD offspring was associated with the BDNF Val66Met polymorphism.64 BD offspring (mean age: 13.73 (S.D.
|
25498133 |
2015 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met polymorphism and bipolar disorder in European populations: A risk association in case-control, family-based and GWAS studies.
|
27236043 |
2016 |