|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Val66Met polymorphism of the BDNF gene is unrelated to the development or clinical features of bipolar disorder, at least in a Japanese population.
|
15336520 |
2004 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder.
|
15543516 |
2004 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The val66met single-nucleotide polymorphism (SNP) showed significant (P = 0.005) association for valine (allele G) with schizophrenia but not bipolar disorder.
|
15630410 |
2005 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Variation at the Val66Met polymorphism of BDNF does not play a major role in influencing susceptibility to bipolar disorder as a whole, but is associated with susceptibility to the rapid-cycling subset of the disorder.
|
16388065 |
2006 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Val66Met polymorphism of the BDNF gene may be associated with cognitive performance on the WCST in bipolar mood disorder but not in schizophrenia.
|
16472361 |
2006 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Lithium response and Val66Met polymorphism of the brain-derived neurotrophic factor gene in Japanese patients with bipolar disorder.
|
16538178 |
2006 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analysis reveals no association of the Val66Met polymorphism of brain-derived neurotrophic factor with either schizophrenia or bipolar disorder.
|
17417060 |
2007 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the neurochemistry of the left dorsolateral prefrontal cortex of bipolar disorder and healthy participants in relation to the brain-derived neurotrophic factor val66met polymorphism using H-magnetic resonance spectroscopy.
|
17885603 |
2007 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We performed a family-based association study and ETDT analyses of the Val66Met polymorphism in 312 BD nuclear families, and compared allele-specific mRNA levels in both post-mortem brain samples and B lymphoblasts from BD patients and controls.
|
18606495 |
2008 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that BDNF G196A as well as 5HTT-LPR polymorphisms confer risk for SB in BD, but we did not observe any evidence for an interaction between them.
|
18657242 |
2008 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effects of the brain-derived neurotrophic growth factor val66met variation on hippocampus morphology in bipolar disorder.
|
18704093 |
2009 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Changes in gyrification over 4 years in bipolar disorder and their association with the brain-derived neurotrophic factor valine(66) methionine variant.
|
19167700 |
2009 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study suggests that the markers examined thus far in COMT and SLC6A4 are not associated with pediatric bipolar disorder and that if the val66met marker in BDNF is associated with pediatric bipolar disorder the magnitude of the association is much smaller than first reported.
|
19193231 |
2009 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The findings support an association between the BDNF Val66Met genotype and differential gray matter content in brain structures, and suggest that the variation in this gene may play a more prominent role in brain structure differences in subjects affected with BD.
|
19295510 |
2009 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Previous studies have suggested that the Val66Met (also known as rs6265 or G196A) variant of BDNF is associated with bipolar disorder (BPD), but the results have been inconclusive.
|
19330778 |
2010 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of the present study was to examine the interplay between the BDNF Val(66)Met polymorphism and stressful life events (SLEs) in bipolar disorder.
|
20172611 |
2010 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further studies are needed to evaluate the genetic association between the val66met allele and the BD-PTSD population, along with central/peripheral BDNF levels and epigenetic patterns of BDNF gene regulation within these patients.
|
21931317 |
2012 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study also adds to the body of evidence associating the functional Val66Met polymorphism of BDNF with BD.
|
22085476 |
2012 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Sixty-six subjects with BD (41 in manic and 25 in depressive episodes) and 78 healthy volunteers were genotyped for BDNF Val(66)Met and tested for creativity using the Barrow Welsh Art Scale (BWAS) and neuropsychological tests.
|
22484201 |
2012 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined the association between the BDNF Val66Met and DRD3 Ser9Gly polymorphisms with two subtypes of bipolar disorder: bipolar-I and -II.
|
22877924 |
2012 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Val66Met polymorphism at the BDNF gene does not influence Wisconsin Card Sorting Test results in children and adolescents with bipolar disorder.
|
23567599 |
2013 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Val66Met polymorphism and serum brain-derived neurotrophic factor in bipolar disorder: an open-label trial.
|
23957567 |
2014 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Plasma BDNF concentration did not differ by val66met or BD subtype, nor was it correlated with age or illness duration.
|
24398043 |
2014 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia.
|
24468644 |
2014 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF val66met polymorphism is a potential vulnerability factor for cognitive impairment in BD.
|
24862657 |
2014 |