|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genotyping of African-American subjects with schizophrenia for five BDNF coding region single nucleotide polymorphisms revealed variance only at the Val66Met</span> allele.
|
17894414 |
2008 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In an attempt to replicate this finding, we genotyped 206 individuals (92 affected with schizophrenia or a related disorder and 114 unaffected relatives) from the Maudsley Family Study for the BDNF val66 met polymorphism.
|
15719396 |
2005 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the current study, we examined BDNF polymorphisms (G-712A, C270T and Val66Met) in 202 patients with MD and 323 patients with schizophrenia.
|
21129438 |
2011 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the present study, we investigated the association between the Val66Met polymorphism of the gene and schizophrenia in 401 Japanese patients with schizophrenia and 569 controls.
|
16854566 |
2006 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this sample, we found a possible interaction between the BDNF Val66Met and DRD3 Ser9Gly SNPs in increasing the risk of suicide attempt(s) in our SCZ sample.
|
25264289 |
2015 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we investigated whether val66met, a functional and abundant missense polymorphism in the coding region of the BDNF gene, was associated with the volume of the hippocampal formation in 19 patients with first-episode schizophrenia and 25 healthy volunteers.
|
15768049 |
2005 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interplay between childhood trauma and BDNF val66met variants on blood BDNF mRNA levels and on hippocampus subfields volumes in schizophrenia spectrum and bipolar disorders.
|
25246365 |
2014 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, in a meta-analysis, the Val66Met polymorphism was not associated with schizophrenia, whereas C270T showed a trend for association in a fixed model (p=0.036), but not in a random model (p=0.053).
|
19406621 |
2009 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
No significant differences in genotype or allele distribution of Val66Met were identified between aggressive and non-aggressive schizophrenia patients.
|
24289908 |
2014 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data provide evidence that the BDNF Val66Met polymorphism may be involved in the etiology of schizophrenia in a Chinese Han population.
|
23532065 |
2013 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data suggested an association between BDNF Val66Met polymorphism and OCS in Egyptian schizophrenia patients.
|
22521161 |
2012 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our finding suggests that this BDNF-gene Val66Met polymorphism may be related to schizophrenia pathogenesis in patients responsive to clozapine treatment.
|
12951204 |
2003 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that the BDNF Val66Met variant is not associated with response to antipsychotics in individuals with SCZ.
|
30181602 |
2019 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our investigation indicates that the BDNF gene Val66Met polymorphism is related to the onset age of schizophrenia and the levels of clinical symptoms that remain after long-term antipsychotic treatment.
|
16533563 |
2006 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our population-based study and meta-analysis demonstrate that the BDNF C-270T and Val66Met polymorphisms do not play major roles in the susceptibility to schizophrenia in either Caucasian or Asian populations.
|
17289348 |
2007 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that BDNF Val66Met variants might influence the response to 8 weeks of monotherapy with olanzapine, in a relatively large sample of patients with schizophrenia.
|
24595507 |
2014 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that the BDNF Val66Met polymorphism may not contribute directly to the susceptibility to schizophrenia, but to the onset of the disease.
|
20420877 |
2010 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Plasma levels of BDNF were significantly lower in patients with schizophrenia than in healthy controls and patients with bipolar disorder (F = 37.667, p<0.001); the distribution of the BDNF Val66Met SNP was not different between groups (χ(2) = 5.289, p = 0.507).
|
24468644 |
2014 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significant 2-way interactions were found for Val66Met × PN, 3-way interactions were found for Val66Met × PN × PA, and four-way interactions were found for Val66Met × PN × PA × EN with regard to the excitement scores.Our findings suggested an involvement of BDNF Val66Met polymorphism after ChT in terms of risk for schizophrenia symptoms.
|
29595641 |
2018 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Studies have also shown that the BDNF Val66Met polymorphism was associated with weight gain in patients with schizophrenia on long-term antipsychotic treatment.
|
27483421 |
2016 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The val66met single-nucleotide polymorphism (SNP) showed significant (P = 0.005) association for valine (allele G) with schizophrenia but not bipolar disorder.
|
15630410 |
2005 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association between BDNF gene functional Val66Met polymorphism rs6265 and the schizophrenia is far from being consistent.
|
24069289 |
2013 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association between decreased BDNF serum levels and cognitive impairment in schizophrenia is dependent on the BDNF Val66Met polymorphism.
|
22362486 |
2012 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism has an important effect on the age of onset of schizophrenia in a gender-specific manner.
|
21917241 |
2011 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism, which results in deficient activity-dependent secretion of BDNF, is associated with clinical features of schizophrenia.
|
27262112 |
2017 |