rs786202724, MET

N. diseases: 5
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Neoplastic Syndromes, Hereditary
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
0.700 CausalMutation CLINVAR The novel ATP-competitive inhibitor of the MET hepatocyte growth factor receptor EMD1214063 displays inhibitory activity against selected MET-mutated variants. 24061647 2013
Neoplasms
CUI: C0027651
Disease: Neoplasms
0.700 GeneticVariation CLINVAR An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. 17483355 2007
Neoplastic Syndromes, Hereditary
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
0.700 CausalMutation CLINVAR Early onset hereditary papillary renal carcinoma: germline missense mutations in the tyrosine kinase domain of the met proto-oncogene. 15371818 2004
Neoplastic Syndromes, Hereditary
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
0.700 CausalMutation CLINVAR Dysregulation of Met receptor tyrosine kinase activity in invasive tumors. 11927612 2002
Neoplastic Syndromes, Hereditary
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
0.700 CausalMutation CLINVAR Structural basis of oncogenic activation caused by point mutations in the kinase domain of the MET proto-oncogene: modeling studies. 11354004 2001
Neoplastic Syndromes, Hereditary
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
0.700 CausalMutation CLINVAR Hereditary and sporadic papillary renal carcinomas with c-met mutations share a distinct morphological phenotype. 10433944 1999
Neoplastic Syndromes, Hereditary
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
0.700 CausalMutation CLINVAR Novel mutation in the ATP-binding site of the MET oncogene tyrosine kinase in a HPRCC family. 10417759 1999
Type 1 Papillary Renal Cell Carcinoma
CUI: C1336839
Disease: Type 1 Papillary Renal Cell Carcinoma
0.700 GeneticVariation UNIPROT Novel mutation in the ATP-binding site of the MET oncogene tyrosine kinase in a HPRCC family. 10417759 1999
Type 1 Papillary Renal Cell Carcinoma
CUI: C1336839
Disease: Type 1 Papillary Renal Cell Carcinoma
0.700 GeneticVariation UNIPROT Novel mutations of the MET proto-oncogene in papillary renal carcinomas. 10327054 1999
Type 1 Papillary Renal Cell Carcinoma
CUI: C1336839
Disease: Type 1 Papillary Renal Cell Carcinoma
0.700 GeneticVariation UNIPROT Hereditary and sporadic papillary renal carcinomas with c-met mutations share a distinct morphological phenotype. 10433944 1999
Carcinoma
CUI: C0007097
Disease: Carcinoma
0.700 GeneticVariation CLINVAR Novel mutation in the ATP-binding site of the MET oncogene tyrosine kinase in a HPRCC family. 10417759 1999
Type 1 Papillary Renal Cell Carcinoma
CUI: C1336839
Disease: Type 1 Papillary Renal Cell Carcinoma
0.700 GeneticVariation UNIPROT Two North American families with hereditary papillary renal carcinoma and identical novel mutations in the MET proto-oncogene. 9563489 1998
Type 1 Papillary Renal Cell Carcinoma
CUI: C1336839
Disease: Type 1 Papillary Renal Cell Carcinoma
0.700 GeneticVariation UNIPROT Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. 9140397 1997
Renal Cell Carcinoma
CUI: C0007134
Disease: Renal Cell Carcinoma
0.700 CausalMutation CLINVAR