|
Asthma
|
|
0.020 |
GeneticVariation
|
BEFREE |
These findings suggest that specific molecular interactions control TRPV1 activation by particles, differential activation, and desensitization of TRPV1 by particles and/or other agonists, and cellular changes in the expression of TRPA1 as a result of I585V expression could contribute to variations in asthma symptom control.
|
27758864 |
2016 |
|
Asthma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Although none of the SNPs modified the risk of suffering from asthma, carriers of the TRPV1-I585V genetic variant showed a lower risk of current wheezing (odds ratio = 0.51; p = 0.01), a characteristic of active asthma, or cough (odds ratio = 0.57; p = 0.02).
|
20639579 |
2010 |
|
Neuralgia
|
|
0.010 |
GeneticVariation
|
BEFREE |
This demonstrates not only the functional influence of TRPV1 rs8065080 polymorphism itself; it further more underpins the relevance of genotyping-based approaches in both patients and surrogate models of neuropathic pain in healthy volunteers.
|
28817717 |
2017 |
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
People with the minor alleles of the TRPV1 single nucleotide polymorphisms rs161364 and rs8065080 have a lower risk of diabetes with a high-fat diet, but people with the major alleles are at a higher risk of type 2 diabetes when consuming high-fat diets.
|
27287034 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
People with the minor alleles of the TRPV1 single nucleotide polymorphisms rs161364 and rs8065080 have a lower risk of diabetes with a high-fat diet, but people with the major alleles are at a higher risk of type 2 diabetes when consuming high-fat diets.
|
27287034 |
2016 |
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
People with the minor alleles of the TRPV1 single nucleotide polymorphisms rs161364 and rs8065080 have a lower risk of diabetes with a high-fat diet, but people with the major alleles are at a higher risk of type 2 diabetes when consuming high-fat diets.
|
27287034 |
2016 |
|
Knee pain
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis.
|
21616913 |
2011 |
|
Hypoalgesia
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, in neuropathic pain patients transient receptor potential ankyrin 1 710G>A (rs920829, E179K) was associated with the presence of paradoxical heat sensation (p = 0.03), and transient receptor potential vanilloid 1 1911A>G (rs8065080, I585V) with cold hypoalgesia (p = 0.0035).
|
21468319 |
2011 |
|
Osteoarthritis, Knee
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Ile585Val TRPV1 variant encoded by rs8065080 was genotyped in 3270 cases of symptomatic knee OA, 1098 cases of asymptomatic knee OA and 3852 controls from seven cohorts from the UK, the USA and Australia.
|
21616913 |
2011 |
|
Coughing
|
|
0.010 |
GeneticVariation
|
BEFREE |
Although none of the SNPs modified the risk of suffering from asthma, carriers of the TRPV1-I585V genetic variant showed a lower risk of current wheezing (odds ratio = 0.51; p = 0.01), a characteristic of active asthma, or cough (odds ratio = 0.57; p = 0.02).
|
20639579 |
2010 |
|
Wheezing
|
|
0.010 |
GeneticVariation
|
BEFREE |
Although none of the SNPs modified the risk of suffering from asthma, carriers of the TRPV1-I585V genetic variant showed a lower risk of current wheezing (odds ratio = 0.51; p = 0.01), a characteristic of active asthma, or cough (odds ratio = 0.57; p = 0.02).
|
20639579 |
2010 |
|
Childhood asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We now report on the association of two functional SNPs, TRPV1-I585V and TRPV4-P19S, with childhood asthma.
|
20639579 |
2010 |