|
Rheumatoid Arthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate whether the IL-17A -737 T/C (rs8193036), -444A/G (rs3819024), -197G/A (rs2275913), and -121G/A (rs8193037) SNPs conferred susceptibility to SLE (or lupus nephritis) or to RA in a Mexican population.
|
30398030 |
2019 |
|
Rheumatoid Arthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
However, no evidence of association was found between the <i>IL-17F</i> rs2397084, <i>IL-17A</i> rs4711998 and <i>IL-17A</i> rs8193036 polymorphisms and RA susceptibility.
|
28069745 |
2017 |
|
Coronary Artery Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
No significant association was found for rs2275913, rs3819024, rs3819025, rs8193037, rs4711998, and rs8193036 with CAD susceptibility in the overall analysis.
|
27376313 |
2016 |
|
Coronary Artery Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The allelic or genotypic frequencies of the rs8193037 (promoter region) and rs8193036 (promoter region) polymorphisms in CAD were significantly different from those in healthy controls.
|
27525938 |
2016 |
|
Rheumatoid Arthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results indicated that IL17A rs4711998 A/G and IL17A rs8193037 G/A polymorphisms were not associated with RA, and IL17A rs2275913 G/A and IL17A rs3819024 A/G variant alleles decrease the risk of RA, while IL17A rs3819025 G/A and IL17A rs8193036 C/T variant alleles increase the risk of RA.
|
25871515 |
2015 |
|
Coronary Artery Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Moreover, rs3819024 was associated with increased levels of visceral abdominal fat (P = 0.002) and rs8193036 was significantly associated with risk of central obesity (P = 0.020), hypertriglyceridemia (P = 0.027), and metabolic syndrome (P = 0.027) in the premature CAD group, under dominant models adjusted by age, gender, BMI, smoking history, alcohol consumption, and treatment.
|
25615631 |
2015 |
|
Asthma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results revealed that, in an Asian population, IL-17 rs763780, rs2275913, and rs8193036 SNPs may be associated with asthma susceptibility, and GA genotype in rs2275913 and TT genotype in rs8193036 of IL-17 may contribute to increased risk of asthma in Asians.
|
26954344 |
2016 |
|
Asthma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The results indicated an independent role of IL17A promoter polymorphism rs8193036 in the association with pediatric asthma in Taiwanese population.
|
19210369 |
2009 |
|
Respiratory Distress Syndrome, Adult
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggested that two functional polymorphisms of IL-17, rs2275913 and rs8193036 were associated with ARDS</span> risk and prognosis, indicating that the two genetic variants might act as possible markers for the prediction of ARDS risk and development.
|
30655311 |
2019 |
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate whether the IL-17A -737 T/C (rs8193036), -444A/G (rs3819024), -197G/A (rs2275913), and -121G/A (rs8193037) SNPs conferred susceptibility to SLE (or lupus nephritis) or to RA in a Mexican population.
|
30398030 |
2019 |
|
Osteitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The GTA haplotype of the IL17A SNPs rs4711998, rs8193036 and rs2275913 was associated with osteitis after BCG vaccination.
|
28916742 |
2017 |
|
Tuberculosis, Pulmonary
|
|
0.010 |
GeneticVariation
|
BEFREE |
We could not properly analyze IL17A -692 C>T (rs8193036) and IFNG +874T>A due to genotypic inconsistencies and found no evidence of association for the IL2, IL4, IL10 and TNF polymorphisms and PTB.
|
26840977 |
2016 |
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
We also found that two IL-17 haplotypes (G-G-G-A-C) and (A-G-G-A-C) (in the order of rs1974226, rs2275913, rs3819024, rs4711998 and rs8193036) were associated with a reduced GCa risk (adjusted OR = 0.64, 95% CI = 0.46-0.89 and adjusted OR = 0.38, 95% CI = 0.17-0.81, respectively).
|
27577072 |
2016 |
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We also found that two IL-17 haplotypes (G-G-G-A-C) and (A-G-G-A-C) (in the order of rs1974226, rs2275913, rs3819024, rs4711998 and rs8193036) were associated with a reduced GCa risk (adjusted OR = 0.64, 95% CI = 0.46-0.89 and adjusted OR = 0.38, 95% CI = 0.17-0.81, respectively).
|
27577072 |
2016 |
|
Anthracosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs3748067 G > A and rs8193036 C > T polymorphisms decrease CWP risk.
|
26223249 |
2015 |
|
Uveitis, Intermediate
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subsequently, a specific association of both polymorphisms with the diffuse form of the disease was evident in the subphenotype analysis when considering this same genetic model (panuveitis vs posterior and intermediate uveitis: rs8193036, p=0.020; rs2275913, p=0.038).
|
25595174 |
2015 |
|
Cardiomyopathies
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results showed that SNP rs8193036, which is located upstream of the coding region of the gene, was slightly associated with protection against T. cruzi infection (P=0.0170, P(FDR)=0.0851, odds ratio (OR)=0.80, confidence interval (CI)=0.66-0.96) and associated with protection against the development of cardiomyopathy (P=0.0065, P(FDR)=0.0324, OR=0.75, CI=0.60-0.92).
|
26468780 |
2015 |
|
Metabolic Syndrome X
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, rs3819024 was associated with increased levels of visceral abdominal fat (P = 0.002) and rs8193036 was significantly associated with risk of central obesity (P = 0.020), hypertriglyceridemia (P = 0.027), and metabolic syndrome (P = 0.027) in the premature CAD group, under dominant models adjusted by age, gender, BMI, smoking history, alcohol consumption, and treatment.
|
25615631 |
2015 |
|
Gastrointestinal Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
We searched electronic databases (PubMed, Embase, Web of Science, CBM and CNKI) to identify papers, published before October 2014, on associations between polymorphisms in the IL-17 pathway genes (rs2275913, rs763780, rs3748067, rs3819025, rs9382084, rs12203582 and rs8193036) and the risk of gastrointestinal diseases.
|
26164762 |
2015 |
|
Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, rs3819024 was associated with increased levels of visceral abdominal fat (P = 0.002) and rs8193036 was significantly associated with risk of central obesity (P = 0.020), hypertriglyceridemia (P = 0.027), and metabolic syndrome (P = 0.027) in the premature CAD group, under dominant models adjusted by age, gender, BMI, smoking history, alcohol consumption, and treatment.
|
25615631 |
2015 |
|
Hypertriglyceridemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, rs3819024 was associated with increased levels of visceral abdominal fat (P = 0.002) and rs8193036 was significantly associated with risk of central obesity (P = 0.020), hypertriglyceridemia (P = 0.027), and metabolic syndrome (P = 0.027) in the premature CAD group, under dominant models adjusted by age, gender, BMI, smoking history, alcohol consumption, and treatment.
|
25615631 |
2015 |
|
Restless Legs Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Controlling for race, gender, and hemoglobin, carrying two copies of the minor allele for IL1B rs1143643, rs1143634, or rs1143633 or carrying the minor allele for IL17A rs8193036 was associated with increased likelihood of meeting RLS diagnostic criteria.
|
23460603 |
2014 |
|
Hepatitis B
|
|
0.010 |
GeneticVariation
|
BEFREE |
HBV infection resolvers had higher rs8193036 allele T and allele T-containing genotypes than HBV patients or controls.
|
23280722 |
2014 |
|
Impaired cognition
|
|
0.010 |
GeneticVariation
|
BEFREE |
Based on our study, polymorphisms in immune/inflammatory-related genes such as IL-17A rs8193036 and IL-10 1082G/A might be correlated with the risk of PD with cognitive impairment in the Han Chinese population.
|
23485736 |
2013 |
|
Parkinson Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Based on our study, polymorphisms in immune/inflammatory-related genes such as IL-17A rs8193036 and IL-10 1082G/A might be correlated with the risk of PD with cognitive impairment in the Han Chinese population.
|
23485736 |
2013 |