|
Lupus Erythematosus, Systemic
|
|
0.840 |
GeneticVariation
|
BEFREE |
In this cohort, SNP rs9271366 (tag SNP for HLA-DRB1*15:01) confers the highest risk for SLE among the 13 MHC gene alleles that display association with SLE (p = 8.748E-10; OR = 3.5).
|
31032751 |
2019 |
|
Lupus Erythematosus, Systemic
|
|
0.840 |
GeneticVariation
|
BEFREE |
The IRF5-TNPO3 region showed the strongest association and largest OR for SLE (rs10488631: genomic control-adjusted P [Pgcadj ] = 2.61 × 10(-29), OR 2.12 [95% CI 1.88-2.39]), followed by HLA class II on the DQA2-DQB1 loci (rs9275572: Pgcadj = 1.11 × 10(-16), OR 1.62 [95% CI 1.46-1.80] and rs9271366: Pgcadj = 6.46 × 10(-12), OR 2.06 [95% CI 1.71-2.50]).
|
26606652 |
2016 |
|
Lupus Erythematosus, Systemic
|
|
0.840 |
GeneticVariation
|
GWASDB |
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
|
23273568 |
2013 |
|
Lupus Erythematosus, Systemic
|
|
0.840 |
GeneticVariation
|
BEFREE |
Our findings suggest that in addition to some classical HLA variants, rs9271366 and rs9275328 are additional polymorphisms worth considering in the Malaysian and possibly in a larger Asian SLE scenario.
|
23257407 |
2013 |
|
Lupus Erythematosus, Systemic
|
|
0.840 |
GeneticVariation
|
BEFREE |
Our strongest signal, the rs9271366 SNP, was also associated with higher risk of SLE in a previous Chinese genome-wide association study (GWAS).
|
21695597 |
2011 |
|
Lupus Erythematosus, Systemic
|
|
0.840 |
GeneticVariation
|
GWASCAT |
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.
|
19838195 |
2009 |
|
Crohn Disease
|
|
0.820 |
GeneticVariation
|
BEFREE |
The strongest associations were observed between ulcerative colitis and HLA rs9271366 (P = 7.5 × 10(-6)), Crohn's disease and 5p13.1 rs4286721 (P = 3.5 × 10(-6)), and IBD and KAT2A rs730086 (P = 2.3 × 10(-6)).
|
26278503 |
2015 |
|
Crohn Disease
|
|
0.820 |
GeneticVariation
|
GWASDB |
Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.
|
23850713 |
2014 |
|
Crohn Disease
|
|
0.820 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.
|
23850713 |
2014 |
|
Crohn Disease
|
|
0.820 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.
|
23266558 |
2013 |
|
Crohn Disease
|
|
0.820 |
GeneticVariation
|
BEFREE |
The comparative GWAS and the replication study identified significant associations in the major histocompatibility complex region at 6p21 with UC and CD (rs9271366, P = 1.6 × 10⁻⁷⁰; odds ratio [OR] = 4.44).
|
21699788 |
2011 |
|
Crohn Disease
|
|
0.820 |
GeneticVariation
|
GWASCAT |
The comparative GWAS and the replication study identified significant associations in the major histocompatibility complex region at 6p21 with UC and CD (rs9271366, P = 1.6 × 10⁻⁷⁰; odds ratio [OR] = 4.44).
|
21699788 |
2011 |
|
Ulcerative Colitis
|
|
0.810 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians.
|
23511034 |
2013 |
|
Ulcerative Colitis
|
|
0.810 |
GeneticVariation
|
GWASDB |
Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians.
|
23511034 |
2013 |
|
Ulcerative Colitis
|
|
0.810 |
GeneticVariation
|
GWASCAT |
The comparative GWAS and the replication study identified significant associations in the major histocompatibility complex region at 6p21 with UC and CD (rs9271366, P = 1.6 × 10⁻⁷⁰; odds ratio [OR] = 4.44).
|
21699788 |
2011 |
|
Ulcerative Colitis
|
|
0.810 |
GeneticVariation
|
BEFREE |
The comparative GWAS and the replication study identified significant associations in the major histocompatibility complex region at 6p21 with UC and CD (rs9271366, P = 1.6 × 10⁻⁷⁰; odds ratio [OR] = 4.44).
|
21699788 |
2011 |
|
Multiple Sclerosis
|
|
0.800 |
GeneticVariation
|
GWASDB |
Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis.
|
20598377 |
2010 |
|
Multiple Sclerosis
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis.
|
20598377 |
2010 |
|
Multiple Sclerosis
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.
|
19525955 |
2009 |
|
Multiple Sclerosis
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.
|
19525955 |
2009 |
|
Inflammatory Bowel Diseases
|
|
0.710 |
GeneticVariation
|
BEFREE |
The strongest associations were observed between ulcerative colitis and HLA rs9271366 (P = 7.5 × 10(-6)), Crohn's disease and 5p13.1 rs4286721 (P = 3.5 × 10(-6)), and IBD and KAT2A rs730086 (P = 2.3 × 10(-6)).
|
26278503 |
2015 |
|
Inflammatory Bowel Diseases
|
|
0.710 |
GeneticVariation
|
GWASDB |
HLA-Cw*1202-B*5201-DRB1*1502 haplotype increases risk for ulcerative colitis but reduces risk for Crohn's disease.
|
21699788 |
2011 |
|
Inflammatory Bowel Diseases
|
|
0.710 |
GeneticVariation
|
GWASDB |
HLA-Cw*1202-B*5201-DRB1*1502 haplotype increases risk for ulcerative colitis but reduces risk for Crohn's disease.
|
21699788 |
2011 |
|
Immunoglobulin A measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
|
20694011 |
2010 |
|
Protein measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
|
20694011 |
2010 |