rs972936, IGF1;LINC02456

N. diseases: 12
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Forced expiratory volume function
CUI: C0016529
Disease: Forced expiratory volume function
0.700 GeneticVariation GWASCAT New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. 30804560 2019
peak expiratory flow (procedure)
CUI: C1518922
Disease: peak expiratory flow (procedure)
0.700 GeneticVariation GWASCAT New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. 30804560 2019
Vital capacity
CUI: C0042834
Disease: Vital capacity
0.700 GeneticVariation GWASCAT New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. 30804560 2019
Dizziness
CUI: C0012833
Disease: Dizziness
0.010 GeneticVariation BEFREE Patients carrying minor alleles of rs7136446 and rs972936 showed more dizziness and multiple neuropsychiatric symptoms after brain injury. 31787098 2019
Behavioral and psychological symptoms of dementia
CUI: C4285807
Disease: Behavioral and psychological symptoms of dementia
0.010 GeneticVariation BEFREE Patients carrying minor alleles of rs7136446 and rs972936 showed more dizziness and multiple neuropsychiatric symptoms after brain injury. 31787098 2019
Vertigo
CUI: C0042571
Disease: Vertigo
0.010 GeneticVariation BEFREE Patients carrying minor alleles of rs7136446 and rs972936 showed more dizziness and multiple neuropsychiatric symptoms after brain injury. 31787098 2019
Parkinson Disease
CUI: C0030567
Disease: Parkinson Disease
0.010 GeneticVariation BEFREE The present study shows that rs972936 polymorphism may increase susceptibility to PD, especially in males and late-onset patients. 28221705 2017
Diabetes Mellitus, Non-Insulin-Dependent
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE This study aimed to assess the association of serum IGF-1 and IGF binding protein (IGFBP)-3 levels with cognition status and to determine whether IGF-1 rs972936 polymorphism is associated with T2DM with mild cognitive impairment (MCI). 26402757 2015
Mild cognitive disorder
CUI: C1270972
Disease: Mild cognitive disorder
0.010 GeneticVariation BEFREE No significant difference was found in the genotype or allele distribution of IGF-1 rs972936 polymorphism between MCI and control groups. 26402757 2015
Osteoporosis
CUI: C0029456
Disease: Osteoporosis
0.010 GeneticVariation BEFREE By conditional regression analysis, we found that the IGF-1 rs2288377 and rs972936 gene polymorphisms were not associated with the risk of osteoporosis (P < 0.05). 26600491 2015
Alzheimer Disease, Late Onset
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
0.010 GeneticVariation BEFREE After stratification by apolipoprotein E (APOE) ɛ4-carrying status, rs972936</span> polymorphism was only significantly associated with LOAD in non-ApoE ɛ4 allele carriers (genotype P = 0.002, allele P = 0.039). 23089282 2012
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.010 GeneticVariation BEFREE Recently, the identification of polymorphism rs972936 that was associated with both an increased risk of AD and high circulating levels of IGF1 was reported in Southern European population. 23089282 2012