rs987237, TFAP2B

N. diseases: 10
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Obesity
CUI: C0028754
Disease: Obesity
0.740 GeneticVariation BEFREE Two loci significantly associated with obesity in Qataris: the TFAP2B variation (rs987237) (A allele versus G allele: chi-square = 10.3; P = 0.0013) and GNPDA2 variation (rs10938397) (A allele versus G allele: chi-square = 6.15; P = 0.013). 25890290 2015
Obesity
CUI: C0028754
Disease: Obesity
0.740 GeneticVariation BEFREE TFAP2B rs987237 is associated with obesity and has shown interaction with the dietary fat-to-carbohydrate ratio, which has an effect on weight loss. 24081236 2013
Obesity
CUI: C0028754
Disease: Obesity
0.740 GeneticVariation BEFREE Eight loci, rs10968576 (BDNF), rs3817334 (MTCH2), rs1558902 (FTO), rs571312 (MC4R), rs543874 (SEC16B), rs987237 (TFAP2B), rs2867125 (TMEM18) and rs7138803 (FAIM2), were previously known obesity susceptibility loci, and the remaining four loci, rs1514175 (TNNI3K), rs206936 (NUDT3), rs4771122 (MTIF3) and rs2241423 (MAP2K5), were newly identified as BMI loci by the GIANT study. 22041983 2012
Obesity
CUI: C0028754
Disease: Obesity
0.740 GeneticVariation BEFREE The MSRA rs545854 and TFAP2B rs987237 showed nominal associations with central obesity; however, no underlying metabolic phenotypes became obvious, when investigating quantitative metabolic traits. 21674055 2011
Obesity
CUI: C0028754
Disease: Obesity
0.740 GeneticVariation GWASCAT Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. 19557161 2009
Body mass index
CUI: C1305855
Disease: Body mass index
0.700 GeneticVariation GWASCAT Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank. 31453325 2019
Waist Circumference
CUI: C0455829
Disease: Waist Circumference
0.700 GeneticVariation GWASCAT Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank. 31453325 2019
Waist-Hip Ratio
CUI: C0205682
Disease: Waist-Hip Ratio
0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. 30239722 2019
Body mass index
CUI: C1305855
Disease: Body mass index
0.700 GeneticVariation GWASCAT Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. 28448500 2017
Physical Activity Measurement
CUI: C4049938
Disease: Physical Activity Measurement
0.700 GeneticVariation GWASCAT Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. 28448500 2017
Body mass index
CUI: C1305855
Disease: Body mass index
0.700 GeneticVariation GWASCAT Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. 26604143 2016
Finding of body mass index
CUI: C0578022
Disease: Finding of body mass index
0.700 GeneticVariation GWASDB Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. 23563607 2013
Body mass index procedure
CUI: C0005893
Disease: Body mass index procedure
0.700 GeneticVariation GWASDB Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. 23001569 2013
Finding of body mass index
CUI: C0578022
Disease: Finding of body mass index
0.700 GeneticVariation GWASDB Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. 23001569 2013
Body mass index
CUI: C1305855
Disease: Body mass index
0.700 GeneticVariation GWASCAT Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. 23563607 2013
Body mass index procedure
CUI: C0005893
Disease: Body mass index procedure
0.700 GeneticVariation GWASDB Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. 23563607 2013
Body mass index
CUI: C1305855
Disease: Body mass index
0.700 GeneticVariation GWASCAT Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. 20935630 2010
Finding of body mass index
CUI: C0578022
Disease: Finding of body mass index
0.700 GeneticVariation GWASDB Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. 20935630 2010
Body mass index procedure
CUI: C0005893
Disease: Body mass index procedure
0.700 GeneticVariation GWASDB Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. 20935630 2010
adiposity
CUI: C1563743
Disease: adiposity
0.700 GeneticVariation GWASDB Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. 19557161 2009
Diabetes Mellitus
CUI: C0011849
Disease: Diabetes Mellitus
0.010 GeneticVariation BEFREE Association of allelic variants in rs2681472 and rs2681492 with hypertension, rs987237 and rs7826222 with waist circumference and rs864745, rs7578597 and rs2943641 with diabetes were not significant. 23036851 2013
Diabetes
CUI: C0011847
Disease: Diabetes
0.010 GeneticVariation BEFREE Association of allelic variants in rs2681472 and rs2681492 with hypertension, rs987237 and rs7826222 with waist circumference and rs864745, rs7578597 and rs2943641 with diabetes were not significant. 23036851 2013