Source: ANIMAL_MODELS

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 101
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 138
IL6 P05231 interleukin 6 0.32 0.248 0.962 54
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 92
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 42
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 86
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 38
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 76
ALB P02768 albumin Transporter 0.64 0.317 0.962 10
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 45
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 24
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 94
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 22
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 47
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 64
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 58
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 44
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 35
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923 62
SPP1 P10451 secreted phosphoprotein 1 2.1E-06 0.353 0.885 17
NFE2L2 Q16236 nuclear factor, erythroid 2 like 2 Enzyme 3.6E-03 0.357 0.885 23
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 37
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885 48
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 41