Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
EGFR-AS1 EGFR antisense RNA 1 0.722 0.192 5 12
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 66 35
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 23 28
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 71 21
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 107 343
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 23 50
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 37 14
AKT2 P31751 AKT serine/threonine kinase 2 Kinase 0.64 0.474 0.769 4 4
MAP2K1 Q02750 mitogen-activated protein kinase kinase 1 Kinase 0.90 0.439 0.846 26 30
IRF1 P10914 interferon regulatory factor 1 Transcription factor 0.99 0.468 0.769 2 2
STK11 Q15831 serine/threonine kinase 11 Kinase 0.99 0.435 0.808 22 129
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 125 84
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 85 55