Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 125 84
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 107 343
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 85 55
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 71 21
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 66 35
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 37 14
MAP2K1 Q02750 mitogen-activated protein kinase kinase 1 Kinase 0.90 0.439 0.846 26 30
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 23 50
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 23 28
STK11 Q15831 serine/threonine kinase 11 Kinase 0.99 0.435 0.808 22 129
EGFR-AS1 EGFR antisense RNA 1 0.722 0.192 5 12
AKT2 P31751 AKT serine/threonine kinase 2 Kinase 0.64 0.474 0.769 4 4
IRF1 P10914 interferon regulatory factor 1 Transcription factor 0.99 0.468 0.769 2 2