Source: CGI

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885 20
PMS2 P54278 PMS1 homolog 2, mismatch repair system component Nucleic acid binding 4.5E-27 0.484 0.808 10
NBN O60934 nibrin Nucleic acid binding 2.2E-16 0.467 0.808 4
IDH1 O75874 isocitrate dehydrogenase (NADP(+)) 1 2.6E-12 0.424 0.808 9
ATR Q13535 ATR serine/threonine kinase Kinase 3.5E-09 0.456 0.923 16
ALK Q9UM73 ALK receptor tyrosine kinase Kinase 3.2E-06 0.396 0.846 11
CDKN2B P42772 cyclin dependent kinase inhibitor 2B 7.3E-03 0.417 0.769 2
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 27
ACVR1 Q04771 activin A receptor type 1 Kinase 0.33 0.535 0.731 1
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 28
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 8
CDKN2C P42773 cyclin dependent kinase inhibitor 2C 0.40 0.527 0.654 3
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 39
NF1 P21359 neurofibromin 1 Enzyme modulator 0.90 0.440 0.885 8
KLF6 Q99612 Kruppel like factor 6 Nucleic acid binding 0.98 0.501 0.846 8
PIK3R1 P27986 phosphoinositide-3-kinase regulatory subunit 1 Kinase 1.00 0.477 0.885 8
MDM2 Q00987 MDM2 proto-oncogene Nucleic acid binding 1.00 0.362 0.846 4
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 45
CIC Q96RK0 capicua transcriptional repressor 1.00 0.523 0.692 2
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 33
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 18
STAG2 Q8N3U4 stromal antigen 2 Nucleic acid binding 1.00 0.568 0.731 12
FUBP1 Q96AE4 far upstream element binding protein 1 Enzyme 1.00 0.610 0.615 1