Source: CGI

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 39
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 20
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 18
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 10
RAC1 P63000 Rac family small GTPase 1 Enzyme modulator 0.76 0.429 0.962 3
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 33
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 33
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 27
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 22
ATR Q13535 ATR serine/threonine kinase Kinase 3.5E-09 0.456 0.923 16
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923 14
CASP8 Q14790 caspase 8 Enzyme 3.7E-06 0.404 0.923 6
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 6
CD274 Q9NZQ7 CD274 molecule Receptor 1.9E-02 0.324 0.923 4
ABL1 P00519 ABL proto-oncogene 1, non-receptor tyrosine kinase Kinase 1.00 0.432 0.923 3
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923 3
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 3
MYD88 Q99836 MYD88 innate immune signal transduction adaptor Enzyme modulator 0.12 0.414 0.923 3
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923 3
CALR P27797 calreticulin Calcium-binding protein 0.89 0.413 0.923 2
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 1
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 29
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 28
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 23