Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 1511 83
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 1193 57
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 960 48
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 703 681
NOTCH1 P46531 notch receptor 1 1.00 0.369 0.885 693 64
EZH2 Q15910 enhancer of zeste 2 polycomb repressive complex 2 subunit Epigenetic regulator 1.00 0.376 0.885 653 35
RET P07949 ret proto-oncogene Kinase 1.00 0.392 0.885 607 162
PTCH1 Q13635 patched 1 1.00 0.398 0.885 604 194
FLNA P21333 filamin A 1.00 0.419 0.846 571 85
NFKB1 P19838 nuclear factor kappa B subunit 1 Transcription factor 1.00 0.396 0.923 551 52
KMT2A Q03164 lysine methyltransferase 2A 1.00 0.410 0.885 535 65
NOS1 P29475 nitric oxide synthase 1 1.00 0.408 0.885 521 38
DNMT1 P26358 DNA methyltransferase 1 Epigenetic regulator 1.00 0.406 0.885 496 36
COL1A1 P02452 collagen type I alpha 1 chain 1.00 0.430 0.808 487 337
DMD P11532 dystrophin 1.00 0.423 0.923 484 345
WNK1 Q9H4A3 WNK lysine deficient protein kinase 1 Kinase 1.00 0.416 0.846 460 26
PDGFRA P16234 platelet derived growth factor receptor alpha Kinase 1.00 0.415 0.808 452 44
SETD2 Q9BYW2 SET domain containing 2, histone lysine methyltransferase Epigenetic regulator 1.00 0.424 0.846 447 23
CREBBP Q92793 CREB binding protein 1.00 0.428 0.808 438 123
JAG1 P78504 jagged canonical Notch ligand 1 1.00 0.429 0.808 420 63
CHD7 Q9P2D1 chromodomain helicase DNA binding protein 7 1.00 0.441 0.846 419 247
TSC2 P49815 TSC complex subunit 2 Enzyme modulator 1.00 0.439 0.808 410 317
PTPRC P08575 protein tyrosine phosphatase receptor type C Enzyme 1.00 0.435 0.808 366 18
SMARCA4 P51532 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Epigenetic regulator 1.00 0.450 0.885 347 73