Source: LHGDN

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
NFKB1 P19838 nuclear factor kappa B subunit 1 Transcription factor 1.00 0.396 0.923 72
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 64
NOTCH1 P46531 notch receptor 1 1.00 0.369 0.885 34
PDGFRA P16234 platelet derived growth factor receptor alpha Kinase 1.00 0.415 0.808 34
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 27
RET P07949 ret proto-oncogene Kinase 1.00 0.392 0.885 22
FLT4 P35916 fms related receptor tyrosine kinase 4 Kinase 1.00 0.457 0.808 17
JAG1 P78504 jagged canonical Notch ligand 1 1.00 0.429 0.808 15
L1CAM P32004 L1 cell adhesion molecule 1.00 0.475 0.769 12
LRP1 Q07954 LDL receptor related protein 1 1.00 0.482 0.769 12
EZH2 Q15910 enhancer of zeste 2 polycomb repressive complex 2 subunit Epigenetic regulator 1.00 0.376 0.885 11
ROCK1 Q13464 Rho associated coiled-coil containing protein kinase 1 Kinase 1.00 0.513 0.731 11
VCAN P13611 versican Extracellular structure 1.00 0.497 0.808 10
PRKDC P78527 protein kinase, DNA-activated, catalytic subunit Kinase 1.00 0.540 0.808 10
TJP1 Q07157 tight junction protein 1 Cell-cell junction 1.00 0.576 0.692 10
ADAM10 O14672 ADAM metallopeptidase domain 10 1.00 0.489 0.846 8
MTA1 Q13330 metastasis associated 1 Nucleic acid binding 1.00 0.547 0.692 7
SLIT2 O94813 slit guidance ligand 2 1.00 0.511 0.769 7
PKD1 P98161 polycystin 1, transient receptor potential channel interacting 1.00 0.493 0.769 6
EPHA4 P54764 EPH receptor A4 Kinase 1.00 0.566 0.846 5
ASAP1 Q9ULH1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 1.00 0.556 0.808 3
ARHGAP35 Q9NRY4 Rho GTPase activating protein 35 1.00 0.751 0.269 2
ARID4A P29374 AT-rich interaction domain 4A Transcription factor 1.00 0.769 0.192 2
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 53