Source: LHGDN

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
NFKB1 P19838 nuclear factor kappa B subunit 1 Transcription factor 1.00 0.396 0.923 72
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 64
RB1 P06400 RB transcriptional corepressor 1 Nucleic acid binding 1.00 0.444 0.885 39
NOTCH1 P46531 notch receptor 1 1.00 0.369 0.885 34
PDGFRA P16234 platelet derived growth factor receptor alpha Kinase 1.00 0.415 0.808 34
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 31
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 27
COL1A1 P02452 collagen type I alpha 1 chain 1.00 0.430 0.808 26
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 24
RET P07949 ret proto-oncogene Kinase 1.00 0.392 0.885 22
TSC2 P49815 TSC complex subunit 2 Enzyme modulator 1.00 0.439 0.808 20
DNMT1 P26358 DNA methyltransferase 1 Epigenetic regulator 1.00 0.406 0.885 19
CACNA1A O00555 calcium voltage-gated channel subunit alpha1 A Ion channel 1.00 0.489 0.769 18
FLT4 P35916 fms related receptor tyrosine kinase 4 Kinase 1.00 0.457 0.808 17
NOS1 P29475 nitric oxide synthase 1 1.00 0.408 0.885 16
JAG1 P78504 jagged canonical Notch ligand 1 1.00 0.429 0.808 15
PTCH1 Q13635 patched 1 1.00 0.398 0.885 15
KMT2A Q03164 lysine methyltransferase 2A 1.00 0.410 0.885 13
PTPRC P08575 protein tyrosine phosphatase receptor type C Enzyme 1.00 0.435 0.808 13
SCN1A P35498 sodium voltage-gated channel alpha subunit 1 Ion channel 1.00 0.477 0.808 13
TEK Q02763 TEK receptor tyrosine kinase Kinase 1.00 0.462 0.692 13
TSC1 Q92574 TSC complex subunit 1 1.00 0.440 0.808 13
F8 P00451 coagulation factor VIII Enzyme 1.00 0.542 0.769 12
L1CAM P32004 L1 cell adhesion molecule 1.00 0.475 0.769 12