Source: CGI

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
DICER1 Q9UPY3 dicer 1, ribonuclease III Enzyme 1.00 0.446 0.846 8
ERCC4 Q92889 ERCC excision repair 4, endonuclease catalytic subunit Enzyme 1.4E-12 0.468 0.846 8
FANCC Q00597 FA complementation group C 2.8E-13 0.507 0.808 8
KLF6 Q99612 Kruppel like factor 6 Nucleic acid binding 0.98 0.501 0.846 8
MSH2 P43246 mutS homolog 2 Nucleic acid binding 0.90 0.406 0.808 8
MSH6 P52701 mutS homolog 6 Nucleic acid binding 3.7E-05 0.462 0.731 8
MUTYH Q9UIF7 mutY DNA glycosylase Enzyme 1.3E-18 0.521 0.769 8
NF1 P21359 neurofibromin 1 Enzyme modulator 0.90 0.440 0.885 8
PALB2 Q86YC2 partner and localizer of BRCA2 3.0E-19 0.485 0.769 8
PIK3R1 P27986 phosphoinositide-3-kinase regulatory subunit 1 Kinase 1.00 0.477 0.885 8
PMS1 P54277 PMS1 homolog 1, mismatch repair system component Nucleic acid binding 1.3E-17 0.569 0.654 8
RAD21 O60216 RAD21 cohesin complex component 1.00 0.528 0.846 8
UBR5 O95071 ubiquitin protein ligase E3 component n-recognin 5 1.00 0.597 0.654 8
ARID1A O14497 AT-rich interaction domain 1A 1.00 0.455 0.846 7
CASP10 Q92851 caspase 10 Enzyme 4.6E-12 0.528 0.692 7
CDH1 P12830 cadherin 1 0.15 0.401 0.808 7
CSF3R Q99062 colony stimulating factor 3 receptor Signaling 1.5E-10 0.550 0.692 7
JAK2 O60674 Janus kinase 2 Kinase 0.65 0.385 0.885 7
PIK3CB P42338 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Kinase 1.00 0.322 0.885 7
PRKAR1A P10644 protein kinase cAMP-dependent type I regulatory subunit alpha 1.00 0.401 0.846 7
TSC1 Q92574 TSC complex subunit 1 1.00 0.440 0.808 7
BRIP1 Q9BX63 BRCA1 interacting protein C-terminal helicase 1 Enzyme 6.2E-17 0.507 0.731 6
CASP8 Q14790 caspase 8 Enzyme 3.7E-06 0.404 0.923 6
DCC P43146 DCC netrin 1 receptor 0.99 0.471 0.808 6