Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor signaling molecule 0.80 0.263 0.966 225
IL6 P05231 interleukin 6 0.34 0.287 0.966 177
VEGFA P15692 vascular endothelial growth factor A signaling molecule 2.7E-05 0.298 0.897 171
TP53 P04637 tumor protein p53 transcription factor 0.17 0.251 0.897 170
TGFB1 P01137 transforming growth factor beta 1 signaling molecule 0.17 0.336 0.931 156
MMP9 P14780 matrix metallopeptidase 9 hydrolase; protease 7.0E-18 0.339 0.862 149
IL1B P01584 interleukin 1 beta 0.13 0.312 0.931 111
MTHFR P42898 methylenetetrahydrofolate reductase 1.2E-09 0.354 0.828 111
CXCL8 P10145 C-X-C motif chemokine ligand 8 signaling molecule 0.342 0.862 100
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.38 0.321 0.828 95
MMP2 P08253 matrix metallopeptidase 2 hydrolase; protease 0.84 0.373 0.862 95
ACE P12821 angiotensin I converting enzyme hydrolase; protease 1.6E-37 0.367 0.897 94
IGF1 P05019 insulin like growth factor 1 0.29 0.355 0.828 84
BCL2 P10415 BCL2, apoptosis regulator signaling molecule 0.57 0.312 0.862 83
CCL2 P13500 C-C motif chemokine ligand 2 signaling molecule 0.62 0.353 0.897 82
LEP P41159 leptin 0.39 0.400 0.793 77
NFKB1 P19838 nuclear factor kappa B subunit 1 1.00 0.365 0.931 72
ESR1 P03372 estrogen receptor 1 nucleic acid binding; receptor; transcription factor 1.00 0.355 0.897 71
ADIPOQ Q15848 adiponectin, C1Q and collagen domain containing 5.0E-09 0.485 0.724 67
STAT3 P40763 signal transducer and activator of transcription 3 nucleic acid binding; transcription factor 1.00 0.358 0.862 64
GSTM1 P09488 glutathione S-transferase mu 1 2.0E-03 0.403 0.828 62
HGF P14210 hepatocyte growth factor hydrolase; protease 1.00 0.394 0.793 61
AKT1 P31749 AKT serine/threonine kinase 1 calcium-binding protein; kinase; transfer/carrier protein; transferase 0.98 0.355 0.862 60
GSTT1 P30711 glutathione S-transferase theta 1 1.3E-04 0.419 0.862 55