Source: LHGDN

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 226
IL6 P05231 interleukin 6 0.32 0.248 0.962 177
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 171
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 169
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 156
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 149
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 112
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 110
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 100
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 95
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 95
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 94
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 84
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 83
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 82
LEP P41159 leptin 0.46 0.349 0.846 78
NFKB1 P19838 nuclear factor kappa B subunit 1 Transcription factor 1.00 0.396 0.923 72
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 71
ADIPOQ Q15848 adiponectin, C1Q and collagen domain containing 4.6E-09 0.376 0.885 67
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 64
GSTM1 P09488 glutathione S-transferase mu 1 2.1E-03 0.380 0.923 62
HGF P14210 hepatocyte growth factor Enzyme 1.00 0.374 0.885 61
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 60
GSTT1 P30711 glutathione S-transferase theta 1 1.5E-04 0.393 0.923 55