Source: ORPHANET

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 13
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 8
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 7
ETV6 P41212 ETS variant transcription factor 6 Transcription factor 0.97 0.477 0.731 7
RET P07949 ret proto-oncogene Kinase 1.00 0.392 0.885 7
ALK Q9UM73 ALK receptor tyrosine kinase Kinase 3.2E-06 0.396 0.846 6
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 6
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 5
NKX2-1 P43699 NK2 homeobox 1 Transcription factor 0.36 0.457 0.808 5
NTRK1 P04629 neurotrophic receptor tyrosine kinase 1 Kinase 2.0E-06 0.422 0.808 4
TFG Q92734 trafficking from ER to golgi regulator 0.14 0.595 0.615 4
FOXE1 O00358 forkhead box E1 Transcription factor 0.79 0.573 0.731 3
NTRK3 Q16288 neurotrophic receptor tyrosine kinase 3 Kinase 1.00 0.522 0.692 3
PAX8 Q06710 paired box 8 1.00 0.477 0.731 3
DIRC3 disrupted in renal carcinoma 3 3.4E-07 0.780 0.308 2
ERC1 Q8IUD2 ELKS/RAB6-interacting/CAST family member 1 Enzyme modulator 1.1E-07 0.780 0.385 2
CCDC6 Q16204 coiled-coil domain containing 6 0.58 0.517 0.808 1
EIF1AX P47813 eukaryotic translation initiation factor 1A X-linked Nucleic acid binding 0.91 0.716 0.231 1
GAS8-AS1 O95177 GAS8 antisense RNA 1 0.751 0.192 1
GOLGA5 Q8TBA6 golgin A5 6.0E-05 0.861 0.115 1
LPAR4 Q99677 lysophosphatidic acid receptor 4 G-protein coupled receptor 2.2E-03 0.769 0.346 1
NCOA4 Q13772 nuclear receptor coactivator 4 Transcription factor 2.2E-06 0.619 0.577 1
NDUFA13 Q9P0J0 NADH:ubiquinone oxidoreductase subunit A13 Enzyme 3.8E-06 0.556 0.692 1
PCM1 Q15154 pericentriolar material 1 3.7E-16 0.644 0.615 1