Source: BEFREE

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 2475 28
IL6 P05231 interleukin 6 0.32 0.248 0.962 2132 21
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 1737 58
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 1604 22
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 1533 21
IFNG P01579 interferon gamma 0.47 0.288 0.962 1361 10
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 1334 32
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 1308 143
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 1173 9
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 1160 28
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 1043 27
IL17A Q16552 interleukin 17A 4.3E-02 0.324 0.923 1034 19
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 1030 52
SMUG1 Q53HV7 single-strand-selective monofunctional uracil-DNA glycosylase 1 4.5E-04 0.322 0.923 1029 4
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 999 26
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 994 8
CD274 Q9NZQ7 CD274 molecule Receptor 1.9E-02 0.324 0.923 990 7
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 957 6
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 953 13
CSF2 P04141 colony stimulating factor 2 Signaling 0.83 0.330 0.962 951 4
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 942 62
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 935 11
IL4 P05112 interleukin 4 4.7E-03 0.332 0.962 926 22
IL2 P60568 interleukin 2 0.48 0.336 0.885 894 4