Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 285 1
IL6 P05231 interleukin 6 0.32 0.248 0.962 270 4
POMC P01189 proopiomelanocortin 1.2E-04 0.356 0.846 241 7
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 239 0
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 232 407
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 182 355
IFNA2 P01563 interferon alpha 2 0.442 0.885 170 0
BCHE P06276 butyrylcholinesterase 1.1E-13 0.447 0.923 108 98
BAP1 Q92560 BRCA1 associated protein 1 Enzyme 0.99 0.454 0.731 108 72
GSTP1 P09211 glutathione S-transferase pi 1 1.4E-02 0.383 0.923 103 4
ACHE P22303 acetylcholinesterase (Cartwright blood group) Enzyme 1.00 0.445 0.885 100 3
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 98 61
SLC2A1 P11166 solute carrier family 2 member 1 Transporter 0.99 0.388 0.808 94 70
MET P08581 MET proto-oncogene, receptor tyrosine kinase Kinase 0.97 0.380 0.846 90 28
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 83 37
TSC1 Q92574 TSC complex subunit 1 1.00 0.440 0.808 74 144
ALAD P13716 aminolevulinate dehydratase Enzyme 5.6E-05 0.556 0.615 73 6
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885 72 928
TSC2 P49815 TSC complex subunit 2 Enzyme modulator 1.00 0.439 0.808 72 287
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 68 36
ADIPOQ Q15848 adiponectin, C1Q and collagen domain containing 4.6E-09 0.376 0.885 66 6
ALOX5 P09917 arachidonate 5-lipoxygenase Enzyme 1.2E-06 0.447 0.885 64 4
RELA Q04206 RELA proto-oncogene, NF-kB subunit Transcription factor 1.00 0.406 0.885 63 3
GSTM1 P09488 glutathione S-transferase mu 1 2.1E-03 0.380 0.923 61 1