Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
HECTD4 Q9Y4D8 HECT domain E3 ubiquitin protein ligase 4 1.00 0.743 0.276 20 5
CDKAL1 Q5VV42 CDK5 regulatory subunit associated protein 1 like 1 1.5E-02 0.639 0.483 18 98
TOMM40 O96008 translocase of outer mitochondrial membrane 40 membrane traffic protein 0.99 0.636 0.483 18 20
FTO Q9C0B1 FTO, alpha-ketoglutarate dependent dioxygenase 1.1E-07 0.519 0.828 17 64
FADS1 O60427 fatty acid desaturase 1 0.41 0.636 0.621 14 15
FADS2 O95864 fatty acid desaturase 2 1.00 0.627 0.552 12 84
ZPR1 O75312 ZPR1 zinc finger 0.762 0.276 11 20
PRKAG2 Q9UGJ0 protein kinase AMP-activated non-catalytic subunit gamma 2 enzyme modulator 1.00 0.614 0.414 11 16
BUD13 Q9BRD0 BUD13 homolog 2.3E-06 0.752 0.448 11 15
CETP P11597 cholesteryl ester transfer protein 1.0E-23 0.555 0.655 10 69
CACNA1C Q13936 calcium voltage-gated channel subunit alpha1 C 1.00 0.575 0.517 10 32
LPA P08519 lipoprotein(a) hydrolase; protease 5.8E-88 0.489 0.655 10 6
ABCA1 O95477 ATP binding cassette subfamily A member 1 transporter 3.5E-12 0.484 0.793 9 34
UBE2L3 P68036 ubiquitin conjugating enzyme E2 L3 ligase 0.84 0.701 0.310 9 24
CUBN O60494 cubilin 2.5E-40 0.630 0.586 9 8
ESR1 P03372 estrogen receptor 1 nucleic acid binding; receptor; transcription factor 1.00 0.355 0.897 8 61
LPL P06858 lipoprotein lipase hydrolase; storage protein 7.2E-10 0.504 0.724 8 49
APOB P04114 apolipoprotein B 1.6E-16 0.477 0.724 8 32
MYRF Q9Y2G1 myelin regulatory factor 1.00 0.727 0.310 8 32
NOS1AP O75052 nitric oxide synthase 1 adaptor protein signaling molecule 0.62 0.652 0.345 8 31
NECTIN2 Q92692 nectin cell adhesion molecule 2 0.701 0.517 8 29
HNF1B P35680 HNF1 homeobox B nucleic acid binding; transcription factor 1.00 0.526 0.621 8 18
TMEM258 P61165 transmembrane protein 258 1.6E-03 0.928 0.069 8 7
MLXIPL Q9NP71 MLX interacting protein like 4.9E-02 0.577 0.655 7 23