Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 85 55
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 84 390
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 71 21
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 70 52
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 66 35
GNAS O95467 P63092 P84996 Q5JWF2 GNAS complex locus Enzyme modulator 0.68 0.420 0.885 60 27
CREBBP Q92793 CREB binding protein 1.00 0.428 0.808 40 115
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 37 14
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 33 582
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885 27 63
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 22 83
IDH1 O75874 isocitrate dehydrogenase (NADP(+)) 1 2.6E-12 0.424 0.808 18 2
NFE2L2 Q16236 nuclear factor, erythroid 2 like 2 Enzyme 3.6E-03 0.357 0.885 10 8
IDH2 P48735 isocitrate dehydrogenase (NADP(+)) 2 0.88 0.434 0.808 9 5
SF3B2 Q13435 splicing factor 3b subunit 2 1.00 0.780 0.308 9 2
SF3B1 O75533 splicing factor 3b subunit 1 Nucleic acid binding 1.00 0.511 0.731 8 9
CNOT9 Q92600 CCR4-NOT transcription complex subunit 9 0.99 0.769 0.192 5 4
RXRA P19793 retinoid X receptor alpha Nuclear receptor 1.00 0.543 0.769 3 1
CASP8 Q14790 caspase 8 Enzyme 3.7E-06 0.404 0.923 2 2
IGF2R P11717 insulin like growth factor 2 receptor Receptor 1.00 0.518 0.731 1 2
AXIN1 O15169 axin 1 0.41 0.559 0.577 1 1