Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 2724 31
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 2494 527
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 1558 50
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 1456 27
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 1337 31
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 1174 54
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 1082 82
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 1049 62
HLA-DRB1 P01911 major histocompatibility complex, class II, DR beta 1 Immune response 1.1E-03 0.333 0.923 1018 185
CD274 Q9NZQ7 CD274 molecule Receptor 1.9E-02 0.324 0.923 1011 8
ABCB1 P08183 ATP binding cassette subfamily B member 1 Transporter 1.3E-05 0.344 0.885 933 59
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 794 14
EGF P01133 epidermal growth factor 8.5E-17 0.357 0.923 774 33
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 765 43
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923 754 47
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962 737 18
FN1 P02751 fibronectin 1 Signaling 1.4E-03 0.365 0.962 724 33
REN P00797 renin Enzyme 2.4E-07 0.370 0.923 721 25
HLA-B P01889 major histocompatibility complex, class I, B 3.9E-05 0.379 0.885 706 308
HLA-A P04439 major histocompatibility complex, class I, A 1.3E-03 0.370 0.846 672 82
HGF P14210 hepatocyte growth factor Enzyme 1.00 0.374 0.885 671 22
MPO P05164 myeloperoxidase Enzyme 7.1E-15 0.377 0.923 653 25
EPHB2 P29323 EPH receptor B2 Kinase 1.00 0.374 0.846 649 19
CXCL10 P02778 C-X-C motif chemokine ligand 10 Signaling 0.37 0.378 0.885 631 9