Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5327
Gene Symbol: PLAT
PLAT
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Biomarker RGD Temporal profile of tissue plasminogen activator (tPA) and inhibitor expression after transient focal cerebral ischemia. 14512838

2003

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Therapeutic RGD Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury. 29498696

2018

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Therapeutic RGD Protective effect of naringenin in experimental ischemic stroke: down-regulated NOD2, RIP2, NF-κB, MMP-9 and up-regulated claudin-5 expression. 24842554

2014

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Therapeutic RGD Hypertonic saline alleviates cerebral edema by inhibiting microglia-derived TNF-α and IL-1β-induced Na-K-Cl Cotransporter up-regulation. 24916922

2014

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Therapeutic RGD Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury. 29498696

2018

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Biomarker RGD Effects of the sigma-1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)-piperazine dihydro-chloride on inflammation after stroke. 23028794

2012

Entrez Id: 718
Gene Symbol: C3
C3
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Biomarker RGD Proteomic analysis of rat plasma following transient focal cerebral ischemia. 22103620

2011

Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.210 Therapeutic RGD 4'-O-β-D-Glucosyl-5-O-Methylvisamminol, A Natural Histone H3 Phosphorylation Epigenetic Suppressor, Exerts a Neuroprotective Effect Through PI3K/Akt Signaling Pathway on Focal Cerebral Ischemia in Rats. 26868427

2016

Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.210 Therapeutic RGD Nicotinamide prevents the down-regulation of MEK/ERK/p90RSK signaling cascade in brain ischemic injury. 21891976

2012

Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.210 Therapeutic RGD By improving regional cortical blood flow, attenuating mitochondrial dysfunction and sequential apoptosis galangin acts as a potential neuroprotective agent after acute ischemic stroke. 23143152

2012

Entrez Id: 6558
Gene Symbol: SLC12A2
SLC12A2
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.210 Therapeutic RGD Inhibition of Na(+)-K(+)-Cl(-) cotransporter during focal cerebral ischemia decreases edema and neuronal damage. 12535773

2003

Entrez Id: 572
Gene Symbol: BAD
BAD
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Nicotinamide prevents the down-regulation of MEK/ERK/p90RSK signaling cascade in brain ischemic injury. 21891976

2012

Entrez Id: 4099
Gene Symbol: MAG
MAG
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Identification of neuroprotective properties of anti-MAG antibody: a novel approach for the treatment of stroke? 15678116

2005

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Lipoxin A4 ameliorates cerebral ischaemia/reperfusion injury through upregulation of nuclear factor erythroid 2-related factor 2. 23880501

2013

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Eriodictyol-7-O-glucoside activates Nrf2 and protects against cerebral ischemic injury. 24466583

2013

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury. 29498696

2018

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD The neuroprotective effects of Tanshinone IIA are associated with induced nuclear translocation of TORC1 and upregulated expression of TORC1, pCREB and BDNF in the acute stage of ischemic stroke. 20417695

2010

Entrez Id: 8883
Gene Symbol: NAE1
NAE1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Focal transient ischemia increases APP-BP1 expression in neural progenitor cells. 21386696

2011

Entrez Id: 5074
Gene Symbol: PAWR
PAWR
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Neuroprotective effect of ghrelin is associated with decreased expression of prostate apoptosis response-4. 19352052

2009

Entrez Id: 665
Gene Symbol: BNIP3L
BNIP3L
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Differential profile of Nix upregulation and translocation during hypoxia/ischaemia in vivo versus in vitro. 15902200

2005

Entrez Id: 839
Gene Symbol: CASP6
CASP6
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD 4'-O-β-D-Glucosyl-5-O-Methylvisamminol, A Natural Histone H3 Phosphorylation Epigenetic Suppressor, Exerts a Neuroprotective Effect Through PI3K/Akt Signaling Pathway on Focal Cerebral Ischemia in Rats. 26868427

2016

Entrez Id: 3037
Gene Symbol: HAS2
HAS2
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Use of suppression subtractive hybridization for differential gene expression in stroke: discovery of CD44 gene expression and localization in permanent focal stroke in rats. 11283406

2001

Entrez Id: 56963
Gene Symbol: RGMA
RGMA
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD CRMP-2 is involved in axon growth inhibition induced by RGMa in vitro and in vivo. 23275173

2013

Entrez Id: 10014
Gene Symbol: HDAC5
HDAC5
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury. 23480850

2013

Entrez Id: 1440
Gene Symbol: CSF3
CSF3
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Induction of granulocyte colony-stimulating factor mRNA by focal cerebral ischemia and cortical spreading depression. 15530654

2004