Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Protective effect of treatment with low-dose gliclazide in a model of middle cerebral artery occlusion and reperfusion in rats. 24602692

2014

Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Glibenclamide enhances neurogenesis and improves long-term functional recovery after transient focal cerebral ischemia. 23149556

2013

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Enalapril attenuates ischaemic brain oedema and protects the blood-brain barrier in rats via an anti-oxidant action. 24471927

2014

Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD The expression of angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas receptor axis are upregulated after acute cerebral ischemic stroke in rats. 24090950

2013

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Neamine induces neuroprotection after acute ischemic stroke in type one diabetic rats. 24211797

2014

Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD The expression of angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas receptor axis are upregulated after acute cerebral ischemic stroke in rats. 24090950

2013

Entrez Id: 9131
Gene Symbol: AIFM1
AIFM1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Bcl-2 transfection via herpes simplex virus blocks apoptosis-inducing factor translocation after focal ischemia in the rat. 15181376

2004

Entrez Id: 203
Gene Symbol: AK1
AK1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD [Comparative proteomic analysis of cerebral cortex between middle cerebral artery occlusion rats and normal controls]. 16468349

2005

Entrez Id: 163
Gene Symbol: AP2B1
AP2B1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration. 19240038

2009

Entrez Id: 317
Gene Symbol: APAF1
APAF1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia-reperfusion injury through suppression of apoptosis and inflammation. 24012531

2013

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Enriched environment reduces apolipoprotein E (ApoE) in reactive astrocytes and attenuates inflammation of the peri-infarct tissue after experimental stroke. 19623195

2009

Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD (-)-Phenserine inhibits neuronal apoptosis following ischemia/reperfusion injury. 28963051

2017

Entrez Id: 361
Gene Symbol: AQP4
AQP4
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia. 20815926

2010

Entrez Id: 23237
Gene Symbol: ARC
ARC
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Erythropoietin-induced changes in brain gene expression reveal induction of synaptic plasticity genes in experimental stroke. 22645329

2012

Entrez Id: 572
Gene Symbol: BAD
BAD
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Nicotinamide prevents the down-regulation of MEK/ERK/p90RSK signaling cascade in brain ischemic injury. 21891976

2012

Entrez Id: 572
Gene Symbol: BAD
BAD
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Ferulic acid prevents the cerebral ischemic injury-induced decrease of Akt and Bad phosphorylation. 22200499

2012

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD By improving regional cortical blood flow, attenuating mitochondrial dysfunction and sequential apoptosis galangin acts as a potential neuroprotective agent after acute ischemic stroke. 23143152

2012

Entrez Id: 63827
Gene Symbol: BCAN
BCAN
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Growth-associated gene expression after stroke: evidence for a growth-promoting region in peri-infarct cortex. 15869933

2005

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD By improving regional cortical blood flow, attenuating mitochondrial dysfunction and sequential apoptosis galangin acts as a potential neuroprotective agent after acute ischemic stroke. 23143152

2012

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD The neuroprotective effects of Tanshinone IIA are associated with induced nuclear translocation of TORC1 and upregulated expression of TORC1, pCREB and BDNF in the acute stage of ischemic stroke. 20417695

2010

Entrez Id: 8678
Gene Symbol: BECN1
BECN1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Beclin 1 knockdown inhibits autophagic activation and prevents the secondary neurodegenerative damage in the ipsilateral thalamus following focal cerebral infarction. 22108007

2012

Entrez Id: 664
Gene Symbol: BNIP3
BNIP3
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD BNIP3 upregulation and EndoG translocation in delayed neuronal death in stroke and in hypoxia. 17379825

2007

Entrez Id: 665
Gene Symbol: BNIP3L
BNIP3L
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Differential profile of Nix upregulation and translocation during hypoxia/ischaemia in vivo versus in vitro. 15902200

2005

Entrez Id: 665
Gene Symbol: BNIP3L
BNIP3L
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Selective inhibition of early--but not late--expressed HIF-1α is neuroprotective in rats after focal ischemic brain damage. 21029239

2011

Entrez Id: 718
Gene Symbol: C3
C3
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Biomarker RGD Proteomic analysis of rat plasma following transient focal cerebral ischemia. 22103620

2011