Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.310 Biomarker CTD_human Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. 15059925

2004

Entrez Id: 59
Gene Symbol: ACTA2
ACTA2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.300 Biomarker CTD_human Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. 15059925

2004

Entrez Id: 72
Gene Symbol: ACTG2
ACTG2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.300 Biomarker CTD_human Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. 15059925

2004

Entrez Id: 219
Gene Symbol: ALDH1B1
ALDH1B1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.310 Biomarker CTD_human Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors. 25641190

2015

Entrez Id: 242
Gene Symbol: ALOX12B
ALOX12B
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.300 Biomarker CTD_human Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers. 30258081

2018

Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.370 Biomarker CTD_human Nicotine promoted colon cancer growth via epidermal growth factor receptor, c-Src, and 5-lipoxygenase-mediated signal pathway. 14569062

2004

Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.370 Biomarker CTD_human Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers. 30258081

2018

Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.370 Biomarker CTD_human A heterotopic xenograft model in athymic mice using HT29 and LoVo human colon cancer cells was used to evaluate the effect of the 5-LOX inhibitor zileuton on tumor growth. 18927292

2008

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human One dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) induces tumours in Min/+ mice by truncation mutations or LOH in the Apc gene. 12034317

2002

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human Neonatal exposure to the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine via breast milk or directly induces intestinal tumors in multiple intestinal neoplasia mice. 10383901

1999

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human Genetic alterations in rat colon tumors induced by heterocyclic amines. 8608549

1996

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human Comet fluorescence in situ hybridization analysis for oxidative stress-induced DNA damage in colon cancer relevant genes. 17192441

2007

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human Specific 5'-GGGA-3'-->5'-GGA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. 7846077

1995

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human Sulindac, 3,3'-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis. 26335331

2015

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human The concentrations of EGFR, LRG1, ITIH4, and F5 in serum correlate with the number of colonic adenomas in ApcPirc/+ rats. 25200834

2014

Entrez Id: 430
Gene Symbol: ASCL2
ASCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.350 Biomarker CTD_human Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. 15059925

2004

Entrez Id: 538
Gene Symbol: ATP7A
ATP7A
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.310 Biomarker CTD_human Thus, ATP7A confers resistance to various anticancer agents on cancer cells and might be a good index of drug resistance in clinical colon cancers. 17510416

2007

Entrez Id: 8313
Gene Symbol: AXIN2
AXIN2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.470 Biomarker CTD_human Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. 21188121

2009

Entrez Id: 578
Gene Symbol: BAK1
BAK1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.300 Biomarker CTD_human Three clones, with Bak protein levels similar to those seen in colon cancer cell lines and significantly lower than those found in the parental cells, were further evaluated. 18349538

2008

Entrez Id: 8314
Gene Symbol: BAP1
BAP1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.310 Biomarker CTD_human Inference on germline BAP1 mutations and asbestos exposure from the analysis of familial and sporadic mesothelioma in a high-risk area. 25231345

2015

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human Bcl-2 overexpression in PhIP-induced colon tumors: cloning of the rat Bcl-2 promoter and characterization of a pathway involving beta-catenin, c-Myc and E2F1. 17404573

2007

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker CTD_human Bcl-2 overexpression in PhIP-induced colon tumors: cloning of the rat Bcl-2 promoter and characterization of a pathway involving beta-catenin, c-Myc and E2F1. 17404573

2007

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker CTD_human Relationship of beta-catenin and Bcl-2 expression to sulindac-induced regression of intestinal tumors in Min mice. 10223192

1999

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker CTD_human gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. 19147571

2009

Entrez Id: 8678
Gene Symbol: BECN1
BECN1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.380 Biomarker CTD_human Inhibition of autophagy enhances anticancer effects of atorvastatin in digestive malignancies. 20876807

2010