Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 GeneticVariation LHGDN Colorectal cancer prevention. 15375803

2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 GeneticVariation LHGDN Prognostic significance of p53 mutations in colon cancer at the population level. 11992552

2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 GeneticVariation LHGDN Genotyping of p53 codon 175 in colorectal cancer. 12761448

2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 GeneticVariation LHGDN Polymorphisms in insulin-related genes predispose to specific KRAS2 and TP53 mutations in colon cancer. 16448675

2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 GeneticVariation LHGDN Evaluation of p53 codon 72 polymorphism in adenocarcinomas of the colon and rectum in La Plata, Argentina. 16552814

2006
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.400 GeneticVariation LHGDN Gender-related survival differences associated with EGFR polymorphisms in metastatic colon cancer. 18413774

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.400 GeneticVariation LHGDN Mutations of epidermal growth factor receptor in colon cancer indicate susceptibility or resistance to gefitinib. 18497962

2008
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.400 GeneticVariation LHGDN Gender-specific association between polymorphism of vascular endothelial growth factor (VEGF 936 C>T) gene and colon cancer in Korea. 18505065

2008
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.400 GeneticVariation LHGDN Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers. 18224685

2008
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.400 GeneticVariation LHGDN Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer. 17241872

2007
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.400 GeneticVariation LHGDN Polymorphisms in insulin-related genes predispose to specific KRAS2 and TP53 mutations in colon cancer. 16448675

2006
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.400 GeneticVariation LHGDN Inhibition of colon cancer cell proliferation by the dietary compound conjugated linoleic acid is mediated by the CDK inhibitor p21CIP1/WAF1. 15880444

2005
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.400 GeneticVariation LHGDN The MLH1 -93 G>A promoter polymorphism and genetic and epigenetic alterations in colon cancer. 18615680

2008
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.400 GeneticVariation LHGDN Vascular endothelial growth factor polymorphisms -1154 G/A and -460 C/T are not associated with VEGF mRNA expression and susceptibility to sporadic colon cancer. 18613756

2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.400 GeneticVariation LHGDN Colorectal cancer prevention. 15375803

2004
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.400 GeneticVariation LHGDN Genetics supersedes epigenetics in colon cancer phenotype. 12957287

2003
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.400 GeneticVariation LHGDN Interactions of peroxisome proliferator-activated receptor {gamma} and diet in etiology of colorectal cancer. 15894676

2005
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.400 GeneticVariation LHGDN Gender-specific association of the VEGF -2578C > A polymorphism in Korean patients with colon cancer. 17695550

2007
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.370 GeneticVariation LHGDN The exclusive pattern of MTHFR allele loss in cases of LOH, suggest that functional MTHFR activity within a tumor might play an important role in the survival and progression of a colonic neoplasm. 12540022

2001
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.370 GeneticVariation LHGDN 5,10-Methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and whites. 12496052

2002
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.370 GeneticVariation LHGDN Association of methylenetetrahydrofolate reductase gene polymorphisms and sex-specific survival in patients with metastatic colon cancer. 17704422

2007
Entrez Id: 332
Gene Symbol: BIRC5
BIRC5
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.340 GeneticVariation LHGDN Gene therapy for colon cancer by adeno-associated viral vector-mediated transfer of survivin Cys84Ala mutant. 15685548

2005
Entrez Id: 8313
Gene Symbol: AXIN2
AXIN2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.330 GeneticVariation LHGDN AXIS inhibition protein 2, orofacial clefts and a family history of cancer. 19119171

2009
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.330 GeneticVariation LHGDN Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. 15308583

2004
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.330 GeneticVariation LHGDN Transcription factor 7-like 2 polymorphism and colon cancer. 18398040

2008