×
Entrez Id:
1636
Gene Symbol:
ACE
ACE
Alzheimer's Disease
0.900
Biomarker
RGD
In this study, we explore the effects of altered angiotensin-converting enzyme (ACE), and investigate the possible mechanisms of perindopril, an ACE inhibitor, on brain structure and function in a rat model of AD , as well as the role that ACE plays in AD .
19080340
2008
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease
0.900
Biomarker
RGD
Key mechanisms underlying netrin-1 prevention of impaired spatial and object memory in Aβ1-42 CA1-injected rats.
30066400
2019
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease
0.900
Biomarker
RGD
Intracerebroventricular streptozotocin impairs adult neurogenesis and cognitive functions via regulating neuroinflammation and insulin signaling in adult rats.
29174383
2018
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
Alzheimer's Disease
0.700
Biomarker
RGD
These results are consistent with a role for APOE in Aβ clearance in AD synapses, and suggest that optimal lipidation of apoE2 compared to E3 and E4 makes an important contribution to Aβ clearance and synaptic function.
22020632
2012
×
Entrez Id:
2932
Gene Symbol:
GSK3B
GSK3B
Alzheimer's Disease
0.700
Biomarker
RGD
Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains.
22982863
2012
×
Entrez Id:
102
Gene Symbol:
ADAM10
ADAM10
Alzheimer's Disease
0.700
Biomarker
RGD
Acrolein induces Alzheimer's disease-like pathologies in vitro and in vivo.
23296102
2013
×
Entrez Id:
4137
Gene Symbol:
MAPT
MAPT
Alzheimer's Disease
0.700
Biomarker
RGD
Involvement of glucose related energy crisis and endoplasmic reticulum stress: Insinuation of streptozotocin induced Alzheimer's like pathology.
29126976
2018
×
Entrez Id:
102
Gene Symbol:
ADAM10
ADAM10
Alzheimer's Disease
0.700
Biomarker
RGD
Effects of aluminium on β-amyloid (1-42) and secretases (APP-cleaving enzymes) in rat brain.
24792732
2014
×
Entrez Id:
3643
Gene Symbol:
INSR
INSR
Alzheimer's Disease
0.600
Biomarker
RGD
Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease.
16627931
2006
×
Entrez Id:
3553
Gene Symbol:
IL1B
IL1B
Alzheimer's Disease
0.600
Biomarker
RGD
Akebia Saponin D attenuates amyloid β-induced cognitive deficits and inflammatory response in rats: involvement of Akt/NF-κB pathway.
22963993
2012
×
Entrez Id:
596
Gene Symbol:
BCL2
BCL2
Alzheimer's Disease
0.600
Biomarker
RGD
[Effects of TX0201 abstracted from heart-regulating formula on spatial learning and regulation of Bax mRNA, Bcl-2 mRNA level in brain of rat with Alzheimer's disease ].
17639989
2007
×
Entrez Id:
627
Gene Symbol:
BDNF
BDNF
Alzheimer's Disease
0.600
Biomarker
RGD
[Effects of proBDNF on cell proliferation and differentiation in hippocampal dentate gyrus in Alzheimer' disease rat model].
20646587
2010
×
Entrez Id:
596
Gene Symbol:
BCL2
BCL2
Alzheimer's Disease
0.600
Biomarker
RGD
Induction of Bcl-2 and Bax was related to hyperphosphorylation of tau and neuronal death induced by okadaic acid in rat brain.
16265626
2005
×
Entrez Id:
3481
Gene Symbol:
IGF2
IGF2
Alzheimer's Disease
0.570
Biomarker
RGD
Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease.
16627931
2006
×
Entrez Id:
3480
Gene Symbol:
IGF1R
IGF1R
Alzheimer's Disease
0.560
Biomarker
RGD
While these disturbances were mostly corrected by restoring receptor function, blockade of the IGF-I receptor exacerbated AD -like pathology in old mutant mice already affected of brain amyloidosis and cognitive derangement.
16274856
2006
×
Entrez Id:
3630
Gene Symbol:
INS
INS
Alzheimer's Disease
0.530
Biomarker
RGD
Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein.
17448147
2007
×
Entrez Id:
581
Gene Symbol:
BAX
BAX
Alzheimer's Disease
0.520
Biomarker
RGD
Induction of Bcl-2 and Bax was related to hyperphosphorylation of tau and neuronal death induced by okadaic acid in rat brain.
16265626
2005
×
Entrez Id:
581
Gene Symbol:
BAX
BAX
Alzheimer's Disease
0.520
Biomarker
RGD
[Effects of TX0201 abstracted from heart-regulating formula on spatial learning and regulation of Bax mRNA, Bcl-2 mRNA level in brain of rat with Alzheimer's disease].
17639989
2007
×
Entrez Id:
4843
Gene Symbol:
NOS2
NOS2
Alzheimer's Disease
0.300
Biomarker
RGD
The role of NOS in the impairment of spatial memory and damaged neurons in rats injected with amyloid beta 25-35 into the temporal cortex.
21163295
2011
×
Entrez Id:
4803
Gene Symbol:
NGF
NGF
Alzheimer's Disease
0.300
Biomarker
RGD
Brain and serum levels of nerve growth factor in a rat model of Alzheimer's disease .
21368378
2011
×
Entrez Id:
1103
Gene Symbol:
CHAT
CHAT
Alzheimer's Disease
0.300
Biomarker
RGD
[Neuroprotective effect of electroacupuncture therapy on damaged cholinergic neurons in rats with Alzheimer's disease].
16834974
2006
×
Entrez Id:
6285
Gene Symbol:
S100B
S100B
Alzheimer's Disease
0.300
Biomarker
RGD
This study aimed to evaluate the effect of 5-week treadmill training, in the icv-SZT model of sporadic AD , on cognitive function, oxidative stress (particularly mediated by NO) and on the astrocyte marker proteins, glial fibrillary acidic protein (GFAP) and S100B .
20953641
2010
×
Entrez Id:
4133
Gene Symbol:
MAP2
MAP2
Alzheimer's Disease
0.300
Biomarker
RGD
An experimental rat model of sporadic Alzheimer's disease and rescue of cognitive impairment with a neurotrophic peptide.
22083255
2012
PPARGC1A
Alzheimer's Disease
0.300
Biomarker
RGD
ERK and p38 inhibitors attenuate memory deficits and increase CREB phosphorylation and PGC-1α levels in Aβ-injected rats.
22510382
2012
×
Entrez Id:
177
Gene Symbol:
AGER
AGER
Alzheimer's Disease
0.300
Biomarker
RGD
Salidroside attenuates beta amyloid-induced cognitive deficits via modulating oxidative stress and inflammatory mediators in rat hippocampus.
23396166
2013