Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Down-regulation of intestinal drug transporters in chronic renal failure in rats. 17135344

2007

Entrez Id: 6721
Gene Symbol: SREBF2
SREBF2
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Increased gene expression of liver SREBP-2 in experimental chronic renal failure. 16814791

2007

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.300 Biomarker RGD Oral sorbent AST-120 increases renal NO synthesis in uremic rats. 18089446

2008

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.210 Biomarker RGD Left ventricular gene expressions of aldosterone synthase, mineralocorticoid receptor, and hydroxysteroid dehydrogenase type 2 were the same in the 3 groups, whereas gene expression of the glucocorticoid receptor was significantly diminished in chronic renal failure rats. 18591458

2008

Entrez Id: 1812
Gene Symbol: DRD1
DRD1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Therapeutic RGD Delivery of recombinant adeno-associated virus-mediated human tissue kallikrein for therapy of chronic renal failure in rats. 18402547

2008

Entrez Id: 50604
Gene Symbol: IL20
IL20
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Interleukin-20 targets renal cells and is associated with chronic kidney disease. 18639518

2008

Entrez Id: 5970
Gene Symbol: RELA
RELA
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction. 18077597

2008

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.290 Therapeutic RGD Effect of exercise on cardiac tissue oxidative and inflammatory mediators in chronic kidney disease. 18797164

2009

Entrez Id: 1234
Gene Symbol: CCR5
CCR5
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.260 Biomarker RGD Role of FTY720 on M1 and M2 macrophages, lymphocytes, and chemokines in 5/6 nephrectomized rats. 19535570

2009

Entrez Id: 1535
Gene Symbol: CYBA
CYBA
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.250 Biomarker RGD Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure. 19420110

2009

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.220 Biomarker RGD Role of FTY720 on M1 and M2 macrophages, lymphocytes, and chemokines in 5/6 nephrectomized rats. 19535570

2009

Entrez Id: 1644
Gene Symbol: DDC
DDC
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Renal dopaminergic system activity in rat remnant kidney up to twenty-six weeks after surgery. 19167406

2009

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.280 Biomarker RGD Multiple antioxidants and L-arginine modulate inflammation and dyslipidemia in chronic renal failure rats. 20199183

2010

Entrez Id: 57817
Gene Symbol: HAMP
HAMP
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.260 Biomarker RGD Erythropoietin regulates intestinal iron absorption in a rat model of chronic renal failure. 20631677

2010

Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.210 Biomarker RGD High-calorie diet with moderate protein restriction prevents cachexia and ameliorates oxidative stress, inflammation and proteinuria in experimental chronic kidney disease. 20820841

2010

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.210 Therapeutic RGD Epoetin delta as an antifibrotic agent in the remnant kidney rat: a possible role for transforming growth factor beta and hepatocyte growth factor. 20424483

2010

Entrez Id: 847
Gene Symbol: CAT
CAT
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure. 20007347

2010

Entrez Id: 38
Gene Symbol: ACAT1
ACAT1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. 19878707

2010

Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Down-regulation of liver drug-metabolizing enzymes in a murine model of chronic renal failure. 20007296

2010

Entrez Id: 9817
Gene Symbol: KEAP1
KEAP1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure. 20007347

2010

Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Inhibition of mineralocorticoid receptor is a renoprotective effect of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pitavastatin. 21119529

2011

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.280 Biomarker RGD Curcumin and enalapril ameliorate renal failure by antagonizing inflammation in 5/6 nephrectomized rats: role of phospholipase and cyclooxygenase. 22031851

2012

Entrez Id: 4842
Gene Symbol: NOS1
NOS1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.230 Therapeutic RGD [Effects of shenshuai II recipe on the protein expressions of Ang II and nNOS in chronic renal failure rats' nephridial tissue]. 23185775

2012

Entrez Id: 3667
Gene Symbol: IRS1
IRS1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Vascular insulin resistance related to endoplasmic reticulum stress in aortas from a rat model of chronic kidney disease. 22942179

2012

Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Lipoprotein lipase deficiency in chronic kidney disease is accompanied by down-regulation of endothelial GPIHBP1 expression. 22009636

2012