Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1812
Gene Symbol: DRD1
DRD1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Therapeutic RGD Delivery of recombinant adeno-associated virus-mediated human tissue kallikrein for therapy of chronic renal failure in rats. 18402547

2008

Entrez Id: 6721
Gene Symbol: SREBF2
SREBF2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD Despite increased SREBP-2 gene expression we found LDL-receptor mRNA level to be lower than in controls, suggesting SREBP-2 independent mechanisms of LDL-receptor transcriptional regulation in CRF rats. 16814791

2007

Entrez Id: 5741
Gene Symbol: PTH
PTH
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.300 Biomarker RGD Dietary phosphate binding and loading alter kidney angiotensin-converting enzyme mRNA and protein content in 5/6 nephrectomized rats. 22517117

2012

Entrez Id: 2057
Gene Symbol: EPOR
EPOR
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.220 Biomarker RGD Down-Regulation of Cardiac Erythropoietin Receptor and its Downstream Activated Signal Transducer Phospho-STAT-5 in a Rat Model of Chronic Kidney Disease. 27468524

2016

Entrez Id: 6582
Gene Symbol: SLC22A2
SLC22A2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.300 Biomarker RGD Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy. 12110012

2002

Entrez Id: 8694
Gene Symbol: DGAT1
DGAT1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Dysregulation of hepatic fatty acid metabolism in chronic kidney disease. 23045433

2013

Entrez Id: 84649
Gene Symbol: DGAT2
DGAT2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Dysregulation of hepatic fatty acid metabolism in chronic kidney disease. 23045433

2013

Entrez Id: 80704
Gene Symbol: SLC19A3
SLC19A3
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Biomarker RGD Effect of chronic kidney disease on the expression of thiamin and folic acid transporters. 21149507

2011

Entrez Id: 10560
Gene Symbol: SLC19A2
SLC19A2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Effect of chronic kidney disease on the expression of thiamin and folic acid transporters. 21149507

2011

Entrez Id: 113235
Gene Symbol: SLC46A1
SLC46A1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Effect of chronic kidney disease on the expression of thiamin and folic acid transporters. 21149507

2011

Entrez Id: 6573
Gene Symbol: SLC19A1
SLC19A1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Effect of chronic kidney disease on the expression of thiamin and folic acid transporters. 21149507

2011

Entrez Id: 384
Gene Symbol: ARG2
ARG2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Effect of chronic renal failure on arginase and argininosuccinate synthetase expression. 16809898

2006

Entrez Id: 873
Gene Symbol: CBR1
CBR1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD Effect of experimental kidney disease on the functional expression of hepatic reductases. 25332430

2015

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.220 Therapeutic RGD Epoetin delta as an antifibrotic agent in the remnant kidney rat: a possible role for transforming growth factor beta and hepatocyte growth factor. 20424483

2010

Entrez Id: 57817
Gene Symbol: HAMP
HAMP
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.570 Biomarker RGD Erythropoietin regulates intestinal iron absorption in a rat model of chronic renal failure. 20631677

2010

Entrez Id: 3164
Gene Symbol: NR4A1
NR4A1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 ModifyingMutation RGD Genetic susceptibility and loss of Nr4a1 enhances macrophage-mediated renal injury in CKD. 24722447

2014

Entrez Id: 5126
Gene Symbol: PCSK2
PCSK2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Ghrelin treatment of chronic kidney disease: improvements in lean body mass and cytokine profile. 18039782

2008

Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.220 Biomarker RGD High-calorie diet with moderate protein restriction prevents cachexia and ameliorates oxidative stress, inflammation and proteinuria in experimental chronic kidney disease. 20820841

2010

Entrez Id: 7412
Gene Symbol: VCAM1
VCAM1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD High-calorie diet with moderate protein restriction prevents cachexia and ameliorates oxidative stress, inflammation and proteinuria in experimental chronic kidney disease. 20820841

2010

Entrez Id: 23560
Gene Symbol: GTPBP4
GTPBP4
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.300 Biomarker RGD Identification of a novel nuclear guanosine triphosphate-binding protein differentially expressed in renal disease. 11316846

2001

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.300 Therapeutic RGD Increased circulating trimethylamine N-oxide contributes to endothelial dysfunction in a rat model of chronic kidney disease. 29247650

2018

Entrez Id: 3240
Gene Symbol: HP
HP
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.230 Biomarker RGD Influence of different stages of experimental chronic kidney disease on rats locomotor and postural skeletal muscles microcirculation. 18569920

2008

Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD Inhibition of mineralocorticoid receptor is a renoprotective effect of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pitavastatin. 21119529

2011

Entrez Id: 50604
Gene Symbol: IL20
IL20
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Interleukin-20 targets renal cells and is associated with chronic kidney disease. 18639518

2008

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Biomarker RGD Left ventricular gene expressions of aldosterone synthase, mineralocorticoid receptor, and hydroxysteroid dehydrogenase type 2 were the same in the 3 groups, whereas gene expression of the glucocorticoid receptor was significantly diminished in chronic renal failure rats. 18591458

2008