Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1191
Gene Symbol: CLU
CLU
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Biomarker RGD Urinary biomarkers track the progression of nephropathy in hypertensive and obese rats. 24325231

2014

Entrez Id: 79602
Gene Symbol: ADIPOR2
ADIPOR2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Biomarker RGD Changes of adiponectin and its receptors in rats following chronic renal failure. 24028144

2014

Entrez Id: 80704
Gene Symbol: SLC19A3
SLC19A3
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Biomarker RGD Effect of chronic kidney disease on the expression of thiamin and folic acid transporters. 21149507

2011

Entrez Id: 55328
Gene Symbol: RNLS
RNLS
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Biomarker RGD Catecholamines regulate the activity, secretion, and synthesis of renalase. 18299506

2008

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Biomarker RGD Left ventricular gene expressions of aldosterone synthase, mineralocorticoid receptor, and hydroxysteroid dehydrogenase type 2 were the same in the 3 groups, whereas gene expression of the glucocorticoid receptor was significantly diminished in chronic renal failure rats. 18591458

2008

Entrez Id: 632
Gene Symbol: BGLAP
BGLAP
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Biomarker RGD Serum osteocalcin and to a lesser extend tartrate-resistant acid phosphatase and urinary pyridinoline and deoxypyridinoline crosslinks were higher in the CRF animals compared to the shams, particularly in the animals of the HPD group with more pronounced CRF. 17365904

2007

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Biomarker RGD Protein expression of Pgp, MRP2, and MRP3 were reduced by more than 40% (p < 0.01) in CRF rats, whereas Oatp2 and Oatp3 expression remained unchanged. 17135344

2007

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Biomarker RGD [Curative machanism of Shenle capsule on 5/6 nephrectomy rats]. 15506291

2004

Entrez Id: 51024
Gene Symbol: FIS1
FIS1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Therapeutic RGD Curcumin prevents mitochondrial dynamics disturbances in early 5/6 nephrectomy: Relation to oxidative stress and mitochondrial bioenergetics. 27801955

2017

Entrez Id: 10059
Gene Symbol: DNM1L
DNM1L
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Therapeutic RGD Curcumin prevents mitochondrial dynamics disturbances in early 5/6 nephrectomy: Relation to oxidative stress and mitochondrial bioenergetics. 27801955

2017

Entrez Id: 6469
Gene Symbol: SHH
SHH
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Sonic hedgehog is a novel tubule-derived growth factor for interstitial fibroblasts after kidney injury. 24744439

2014

Entrez Id: 3164
Gene Symbol: NR4A1
NR4A1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 ModifyingMutation RGD Genetic susceptibility and loss of Nr4a1 enhances macrophage-mediated renal injury in CKD. 24722447

2014

Entrez Id: 8694
Gene Symbol: DGAT1
DGAT1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Dysregulation of hepatic fatty acid metabolism in chronic kidney disease. 23045433

2013

Entrez Id: 84649
Gene Symbol: DGAT2
DGAT2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Dysregulation of hepatic fatty acid metabolism in chronic kidney disease. 23045433

2013

Entrez Id: 8678
Gene Symbol: BECN1
BECN1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach. 24090408

2013

Entrez Id: 664
Gene Symbol: BNIP3
BNIP3
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach. 24090408

2013

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Therapeutic RGD Angiogenic effect of endothelial progenitor cells transfected with telomerase reverse transcriptase on peritubular microvessel in five out of six subtotal nephrectomy rats. 23013219

2012

Entrez Id: 3667
Gene Symbol: IRS1
IRS1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Vascular insulin resistance related to endoplasmic reticulum stress in aortas from a rat model of chronic kidney disease. 22942179

2012

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Vascular insulin resistance related to endoplasmic reticulum stress in aortas from a rat model of chronic kidney disease. 22942179

2012

Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Compared to the controls, the CRF group exhibited severe hypertriglyceridemia, significant reduction of the skeletal muscle, myocardium and adipose tissue LPL mRNA and protein abundance. 22009636

2012

Entrez Id: 10631
Gene Symbol: POSTN
POSTN
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Periostin: novel tissue and urinary biomarker of progressive renal injury induces a coordinated mesenchymal phenotype in tubular cells. 22167593

2012

Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Therapeutic RGD Nicorandil, a K(atp) channel opener, alleviates chronic renal injury by targeting podocytes and macrophages. 22622455

2012

Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Therapeutic RGD 5/6 nephrectomy as a validated rat model mimicking human warfarin-related nephropathy. 22473220

2012

Entrez Id: 1728
Gene Symbol: NQO1
NQO1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Therapeutic RGD Prevention of salt-induced renal injury by activation of NAD(P)H:quinone oxidoreductase 1, associated with NADPH oxidase. 22227174

2012

Entrez Id: 10560
Gene Symbol: SLC19A2
SLC19A2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Effect of chronic kidney disease on the expression of thiamin and folic acid transporters. 21149507

2011