×
Entrez Id: 351
Gene Symbol: APP
APP
Dementia
0.700
Biomarker
LHGDN
Association between progranulin and beta-amyloid in dementia with Lewy bodies.
18955727 2009
×
Entrez Id: 351
Gene Symbol: APP
APP
Dementia
0.700
GeneticVariation
LHGDN
A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia.
18300294 2008
×
Entrez Id: 351
Gene Symbol: APP
APP
Dementia
0.700
AlteredExpression
LHGDN
Plasma amyloid beta-protein and C-reactive protein in relation to the rate of progression of Alzheimer disease.
18541797 2008
×
Entrez Id: 351
Gene Symbol: APP
APP
Dementia
0.700
Biomarker
LHGDN
Validation of amyloid-beta peptides in CSF diagnosis of neurodegenerative dementias.
17339876 2007
×
Entrez Id: 351
Gene Symbol: APP
APP
Dementia
0.700
Biomarker
LHGDN
APP locus duplication in a Finnish family with dementia and intracerebral haemorrhage.17442758 2007
×
Entrez Id: 351
Gene Symbol: APP
APP
Dementia
0.700
Biomarker
LHGDN
Biochemical staging of synucleinopathy and amyloid deposition in dementia with Lewy bodies.
16651889 2006
×
Entrez Id: 351
Gene Symbol: APP
APP
Dementia
0.700
GeneticVariation
LHGDN
APP is an important locus predicting the age at onset of dementia in people with Down syndrome.15184603 2004
×
Entrez Id: 351
Gene Symbol: APP
APP
Dementia
0.700
Biomarker
LHGDN
Patients who progressed to DAT at the 2-year follow-up (n = 12) showed a significant decrease of baseline platelet APP forms ratio values (mean +/- SD, 0.36 +/- 0.28) compared with stable MCI subjects (mean +/- SD, 0.73 +/- 0.32) (P<.01) and patients who developed other types of dementia (mean +/- SD, 0.83 +/- 0.27) (P =.03).
14676049 2003
×
Entrez Id: 2896
Gene Symbol: GRN
GRN
Dementia
0.500
Biomarker
LHGDN
We were able to demonstrate progranulin immunoreactivity throughout the medial temporal lobe in all dementia with Lewy body cases.
18955727 2009
×
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
Dementia
0.500
GeneticVariation
LHGDN
Novel PRNP mutation in a patient with a slow progressive dementia syndrome.
18443555 2008
×
Entrez Id: 2896
Gene Symbol: GRN
GRN
Dementia
0.500
GeneticVariation
LHGDN
In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17.
18322394 2008
×
Entrez Id: 2896
Gene Symbol: GRN
GRN
Dementia
0.500
GeneticVariation
LHGDN
Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia.
18183624 2008
×
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
Dementia
0.500
Biomarker
LHGDN
In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17.
18322394 2008
×
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
Dementia
0.500
GeneticVariation
LHGDN
A novel insertional mutation in the prion protein gene: clinical and bio-molecular findings.
19010951 2008
×
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
Dementia
0.500
Biomarker
LHGDN
In this study, we screened the PRNP gene to evaluate the frequency of PRNP mutations and their correlations with clinical phenotype in 185 sporadic neurodegenerative dementia cases and 310 control subjects.
18425766 2008
×
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
Dementia
0.500
GeneticVariation
LHGDN
The extended tau haplotype and the age of onset of dementia in Down syndrome.
18765933 2008
×
Entrez Id: 2896
Gene Symbol: GRN
GRN
Dementia
0.500
Biomarker
LHGDN
Progranulin mutation causes frontotemporal dementia in the Swedish Karolinska family.
19012866 2008
×
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
Dementia
0.500
GeneticVariation
LHGDN
The tau S305S mutation causes frontotemporal dementia with parkinsonism.
18093153 2008
×
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
Dementia
0.500
Biomarker
LHGDN
CSF total and phosphorylated tau protein, regional glucose metabolism and dementia severity in Alzheimer's disease.
18803648 2008
×
Entrez Id: 2896
Gene Symbol: GRN
GRN
Dementia
0.500
GeneticVariation
LHGDN
Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival.
18378771 2008
×
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
Dementia
0.500
GeneticVariation
LHGDN
Although rare, a tau-related dementia with mutations in the microtubule-associated protein tau gene (MAPT) has been identified in patients showing clinical presentations similar to those of AD.
18587238 2008
×
Entrez Id: 5664
Gene Symbol: PSEN2
PSEN2
Dementia
0.500
GeneticVariation
LHGDN
We describe an Italian family with hereditary dementia associated with a novel mutation in the presenilin 2 gene.
18427071 2008
×
Entrez Id: 2896
Gene Symbol: GRN
GRN
Dementia
0.500
Biomarker
LHGDN
Loss-of-function mutations in progranulin (GRN ) cause ubiquitin- and TAR DNA-binding protein 43 (TDP-43)-positive frontotemporal dementia (FTLD-U), a progressive neurodegenerative disease affecting approximately 10% of early-onset dementia patients.
18723524 2008
×
Entrez Id: 2896
Gene Symbol: GRN
GRN
Dementia
0.500
GeneticVariation
LHGDN
It also demonstrates that half of the patients with a PGRN mutation in our series had no apparent family history of dementia .
17436289 2007
×
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
Dementia
0.500
GeneticVariation
LHGDN
The novel Tau mutation G335S: clinical, neuropathological and molecular characterization.
17186252 2007