|
POU5F1P3
|
Malignant neoplasm of breast
|
0.100 |
GeneticVariation |
BEFREE |
All data demonstrated a distinctive expression pattern of OCT4 spliced variants in different types of breast cancer and provide further evidence for the involvement of embryonic genes in carcinogenesis.
|
27814277 |
2017 |
|
POU5F1P3
|
Malignant neoplasm of breast
|
0.100 |
GeneticVariation |
BEFREE |
Although another POU protein Brn-3 has been shown to be a repressor for BRCA1 (breast-cancer susceptibility gene 1), OCT3 does not repress human or mouse BRCA1/Brca-1 promoters.
|
12841847 |
2003 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
GeneticVariation |
BEFREE |
Also, mRNA expression of transcriptional marker Nanog and Octamer-binding transcription factor 4 (OCT4), known to enhance malignancy and metastasis in lung adenocarcinoma, was suppressed in ZNF746 siRNA-transfected H460 NSCLC cells.
|
24145959 |
2014 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
GeneticVariation |
BEFREE |
Egr1 exerts a promoting effect on cancer metastasis in Oct4-overexpressing lung cancer.
|
31399076 |
2019 |
|
POU5F1P3
|
Glioblastoma
|
0.100 |
GeneticVariation |
BEFREE |
Gene expression profiles of three glioma stem cell line samples, three normal astrocyte samples, three astrocyte overexpressing 4 iPSC-inducing and oncogenic factors (myc(T58A), OCT-4, p53DD, and H-Ras(G12V)) samples, three astrocyte overexpressing 7 iPSC-inducing and oncogenic factors (OCT4, H-Ras(G12V), myc(T58A), p53DD, cyclin D1, CDK4(RC24) and hTERT) samples and three glioblastoma cell line samples were downloaded from the ArrayExpress database (accession: E-MTAB-4771).
|
28952134 |
2017 |
|
POU5F1P3
|
Glioma
|
0.100 |
GeneticVariation |
BEFREE |
Gene expression profiles of three glioma stem cell line samples, three normal astrocyte samples, three astrocyte overexpressing 4 iPSC-inducing and oncogenic factors (myc(T58A), OCT-4, p53DD, and H-Ras(G12V)) samples, three astrocyte overexpressing 7 iPSC-inducing and oncogenic factors (OCT4, H-Ras(G12V), myc(T58A), p53DD, cyclin D1, CDK4(RC24) and hTERT) samples and three glioblastoma cell line samples were downloaded from the ArrayExpress database (accession: E-MTAB-4771).
|
28952134 |
2017 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
GeneticVariation |
BEFREE |
Semi-quantitative Real-Time PCR (RT-PCR) showed that both freshly sorted CD44(+) and CD44(+) cells derived from CD44(+)-initiated tumors expressed the pluripotency genes OCT4/POU5F1, NANOG, SOX2.
|
21124918 |
2010 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
GeneticVariation |
BEFREE |
Ubiquitination-defective mutant of OCT4(K284R) overexpressed cells drastically generated tumor burdens in mice.
|
29511337 |
2018 |
|
POU5F1P3
|
Germ cell tumor
|
0.100 |
GeneticVariation |
BEFREE |
Recently, major progress has been made in identifying gene-products related to germ cell tumor development (testis-specific protein-Y encoded and octamer binding transcription factor 3/4) and in recognizing early changes of germ cells (maturation delay, preneoplastic lesions, and in situ neoplasia).
|
16735607 |
2006 |
|
POU5F1P3
|
Embryonal Carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
Therefore, we examined whether allelic pairing of Oct4 loci also occurs during differentiation of F9 and P19 ECCs.
|
28967672 |
2017 |
|
POU5F1P3
|
Embryonal Carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
OCT3/4 (POU5F1) is an established diagnostic immunohistochemical marker for specific histological variants of human malignant germ cell tumours (GCTs), including the seminomatous types and the stem cell component of non-seminomas, known as embryonal carcinoma.
|
21847120 |
2011 |
|
POU5F1P3
|
Carcinogenesis
|
0.100 |
GeneticVariation |
BEFREE |
All data demonstrated a distinctive expression pattern of OCT4 spliced variants in different types of breast cancer and provide further evidence for the involvement of embryonic genes in carcinogenesis.
|
27814277 |
2017 |
|
POU5F1P3
|
Carcinogenesis
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, the data revealed an alteration in the subcellular distribution of Oct4, possibly due to the inhibition of cytoplasm-to-nucleus translocation during carcinogenesis.
|
22922943 |
2012 |
|
POU5F1P3
|
Breast Carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
Although another POU protein Brn-3 has been shown to be a repressor for BRCA1 (breast-cancer susceptibility gene 1), OCT3 does not repress human or mouse BRCA1/Brca-1 promoters.
|
12841847 |
2003 |
|
POU5F1P3
|
Breast Carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
All data demonstrated a distinctive expression pattern of OCT4 spliced variants in different types of breast cancer and provide further evidence for the involvement of embryonic genes in carcinogenesis.
|
27814277 |
2017 |
|
POU5F1P3
|
Tumor Cell Invasion
|
0.100 |
GeneticVariation |
BEFREE |
This process involves the decreased expression of the stemness-related genes Oct-4 and Nanog and the invasion-related gene MMP-9.
|
23043761 |
2013 |
|
POU5F1P3
|
Primary malignant neoplasm
|
0.100 |
GeneticVariation |
BEFREE |
Also, mRNA expression of transcriptional marker Nanog and Octamer-binding transcription factor 4 (OCT4), known to enhance malignancy and metastasis in lung adenocarcinoma, was suppressed in ZNF746 siRNA-transfected H460 NSCLC cells.
|
24145959 |
2014 |
|
POU5F1P3
|
Primary malignant neoplasm
|
0.100 |
GeneticVariation |
BEFREE |
Egr1 exerts a promoting effect on cancer metastasis in Oct4-overexpressing lung cancer.
|
31399076 |
2019 |
|
POU5F1P3
|
Glioblastoma Multiforme
|
0.100 |
GeneticVariation |
BEFREE |
Gene expression profiles of three glioma stem cell line samples, three normal astrocyte samples, three astrocyte overexpressing 4 iPSC-inducing and oncogenic factors (myc(T58A), OCT-4, p53DD, and H-Ras(G12V)) samples, three astrocyte overexpressing 7 iPSC-inducing and oncogenic factors (OCT4, H-Ras(G12V), myc(T58A), p53DD, cyclin D1, CDK4(RC24) and hTERT) samples and three glioblastoma cell line samples were downloaded from the ArrayExpress database (accession: E-MTAB-4771).
|
28952134 |
2017 |
|
POU5F1P3
|
Adult Glioblastoma
|
0.060 |
GeneticVariation |
BEFREE |
Gene expression profiles of three glioma stem cell line samples, three normal astrocyte samples, three astrocyte overexpressing 4 iPSC-inducing and oncogenic factors (myc(T58A), OCT-4, p53DD, and H-Ras(G12V)) samples, three astrocyte overexpressing 7 iPSC-inducing and oncogenic factors (OCT4, H-Ras(G12V), myc(T58A), p53DD, cyclin D1, CDK4(RC24) and hTERT) samples and three glioblastoma cell line samples were downloaded from the ArrayExpress database (accession: E-MTAB-4771).
|
28952134 |
2017 |
|
POU5F1P3
|
Childhood Glioblastoma
|
0.060 |
GeneticVariation |
BEFREE |
Gene expression profiles of three glioma stem cell line samples, three normal astrocyte samples, three astrocyte overexpressing 4 iPSC-inducing and oncogenic factors (myc(T58A), OCT-4, p53DD, and H-Ras(G12V)) samples, three astrocyte overexpressing 7 iPSC-inducing and oncogenic factors (OCT4, H-Ras(G12V), myc(T58A), p53DD, cyclin D1, CDK4(RC24) and hTERT) samples and three glioblastoma cell line samples were downloaded from the ArrayExpress database (accession: E-MTAB-4771).
|
28952134 |
2017 |
|
POU5F1P3
|
Alzheimer's Disease
|
0.050 |
GeneticVariation |
BEFREE |
Human lymphoblast cells from a male diagnosed with Alzheimer's disease (AD) expressing the TREM2 p.R47H variant were used to generate integration-free induced pluripotent stem cells (iPSCs) by over-expressing episomal-based plasmids harbouring OCT4, SOX2, KLF4, LIN28, L-MYC and p53 shRNA.
|
29902745 |
2018 |
|
POU5F1P3
|
Alzheimer's Disease
|
0.050 |
GeneticVariation |
BEFREE |
Human lymphoblast cells from a male diagnosed with Alzheimer's disease (AD) expressing the TREM2 p.R47H variant were used to generate integration-free induced pluripotent stem cells (iPSCs) by over-expressing episomal-based plasmids harbouring OCT4, SOX2, NANOG, LIN28, c-MYC and L-MYC.
|
29602048 |
2018 |
|
POU5F1P3
|
Alzheimer's Disease
|
0.050 |
GeneticVariation |
BEFREE |
Human lymphoblast cells from a female patient diagnosed with Alzheimer's disease (AD) possessing the missense mutation TREM2 p.R47H were used to generate integration-free induced pluripotent stem cells (iPSCs) employing episomal plasmids expressing OCT4, SOX2, NANOG, LIN28, c-MYC and L-MYC.
|
27789408 |
2016 |
|
POU5F1P3
|
Alzheimer's Disease
|
0.050 |
GeneticVariation |
BEFREE |
Human lymphoblast cells from a male patient diagnosed with Alzheimer's disease (AD) expressing the TREM2 p.R47H variant were used to generate integration-free induced pluripotent stem (iPS) cells employing episomal plasmids expressing OCT4, SOX2, NANOG, LIN28, c-MYC and L-MYC.
|
27345793 |
2016 |