|
POU5F1P3
|
Abnormal behavior
|
0.010 |
Biomarker |
BEFREE |
Though these analogs are not superior than D22 in discriminating among OCTs/PMAT, our findings point to development of compounds with combined ability to inhibit both low-affinity/high-capacity transporters, such as OCT3, and high-affinity/low-capacity transporters, such as SERT, as therapeutics with potentially improved efficacy for treatment of psychiatric disorders.
|
30473490 |
2019 |
|
POU5F1P3
|
Acute lymphocytic leukemia
|
0.010 |
Biomarker |
BEFREE |
Recombinant plasmid pcDNA3.1-OCT4 was constructed and transferred into ALL MSCs by liposome transfection.
|
31159871 |
2019 |
|
POU5F1P3
|
Adenocarcinoma
|
0.020 |
Biomarker |
BEFREE |
Comparative studies of OCT4 in adenocarcinoma and BAC tumor cell cultures demonstrated a dramatically higher expression in the former.
|
19126554 |
2009 |
|
POU5F1P3
|
Adenocarcinoma
|
0.020 |
AlteredExpression |
BEFREE |
A Kaplan-Meier analysis showed that overexpression of Oct-4 was associated with shorter overall survival in all cases, adenocarcinoma, squamous cell carcinoma, MVD-negative, and VEGF-negative subsets.
|
22300949 |
2012 |
|
POU5F1P3
|
Adenocarcinoma of lung (disorder)
|
0.030 |
AlteredExpression |
BEFREE |
Here we investigate the expression of OCT4 human lung adenocarcinoma and bronchioloalveolar carcinoma (BAC) tumor biopsies and tumor-derived primary cell cultures.
|
19126554 |
2009 |
|
POU5F1P3
|
Adenocarcinoma of lung (disorder)
|
0.030 |
AlteredExpression |
BEFREE |
Ectopic expressions of Oct4 and Nanog activated Slug and enhanced the tumor-initiating capability of LAC.
|
21159654 |
2010 |
|
POU5F1P3
|
Adenocarcinoma of lung (disorder)
|
0.030 |
GeneticVariation |
BEFREE |
Also, mRNA expression of transcriptional marker Nanog and Octamer-binding transcription factor 4 (OCT4), known to enhance malignancy and metastasis in lung adenocarcinoma, was suppressed in ZNF746 siRNA-transfected H460 NSCLC cells.
|
24145959 |
2014 |
|
POU5F1P3
|
Adenocarcinoma, Clear Cell
|
0.010 |
Biomarker |
BEFREE |
Staining for OCT4 was increased in serous cystadenocarcinoma, when compared with clear cell carcinoma.
|
23921511 |
2013 |
|
POU5F1P3
|
Adenoma of large intestine
|
0.010 |
AlteredExpression |
BEFREE |
Quantitative real-time polymerase chain reaction (qRT-PCR) was used to examine the mRNA expression levels of MST1, LATS2, YAP, TAZ, TEAD1, CDX2, and OCT4, and western blot (WB) was used to examine the protein expression levels of MST1, YAP, TEAD1, and CDX2 in 30 specimens of human colorectal adenomas, 50 pairs of human CRC tissues, and adjacent nontumorous tissues from CRC patients.
|
24976283 |
2015 |
|
POU5F1P3
|
Adrenal Cortex Diseases
|
0.010 |
Biomarker |
BEFREE |
Co-expression analysis of stem cell (OCT4, SSEA4) and CSC (ALDH1/2, CD44 and LGR5) markers with proliferation marker (KI67) in HG tumors revealed dual positive proliferating stem and CSCs, few non-proliferating stem/CSC (SSEA4<sup>+</sup>/KI67<sup>-</sup> and ALDH1/2<sup>+</sup>/KI67<sup>-</sup>) and only KI67<sup>+</sup> cells in cortex, signifying dynamic populations and interesting cellular hierarchy in cortex region.
|
30121075 |
2018 |
|
POU5F1P3
|
Adrenoleukodystrophy
|
0.010 |
Biomarker |
BEFREE |
We generated two induced pluripotent stem cell (iPSC) lines from X-ALD patients with adrenomyeloneuropathy (AMN) by Sendai virus containing OCT4, SOX2, KLF4 and c-MYC.
|
29065337 |
2017 |
|
POU5F1P3
|
Adrenomyeloneuropathy
|
0.010 |
Biomarker |
BEFREE |
We generated two induced pluripotent stem cell (iPSC) lines from X-ALD patients with adrenomyeloneuropathy (AMN) by Sendai virus containing OCT4, SOX2, KLF4 and c-MYC.
|
29065337 |
2017 |
|
POU5F1P3
|
Adult Acute Lymphocytic Leukemia
|
0.010 |
Biomarker |
BEFREE |
Recombinant plasmid pcDNA3.1-OCT4 was constructed and transferred into ALL MSCs by liposome transfection.
|
31159871 |
2019 |
|
POU5F1P3
|
Adult Fibrosarcoma
|
0.010 |
AlteredExpression |
BEFREE |
Furthermore, it could be demonstrated that downregulation of Oct4 by microRNAs-299-3p in breast cancer and fibrosarcoma cells lead to a decreased invasiveness in a microfluidic chip assay.
|
28426762 |
2017 |
|
POU5F1P3
|
Adult Germ Cell Tumor
|
0.010 |
GeneticVariation |
BEFREE |
Recently, major progress has been made in identifying gene-products related to germ cell tumor development (testis-specific protein-Y encoded and octamer binding transcription factor 3/4) and in recognizing early changes of germ cells (maturation delay, preneoplastic lesions, and in situ neoplasia).
|
16735607 |
2006 |
|
POU5F1P3
|
Adult Glioblastoma
|
0.060 |
Biomarker |
BEFREE |
Our results provide a valuable dataset for understanding gene regulation mechanisms underlying the function of OCT4 in glioblastoma cancer.
|
21960344 |
2011 |
|
POU5F1P3
|
Adult Glioblastoma
|
0.060 |
Biomarker |
BEFREE |
These eGFP-positive-GCs exhibited GSC features and primarily localized to the perivascular region in tumor xenografts, similar to the existence of OCT4-expressing GCs in the perivascular region of human glioblastoma specimens.
|
28216164 |
2018 |
|
POU5F1P3
|
Adult Glioblastoma
|
0.060 |
Biomarker |
BEFREE |
Vinculin accumulated along the leading edges of Oct-3/4 expressing-glioblastoma cells and associated with membrane ruffles during cell migration.
|
21938739 |
2012 |
|
POU5F1P3
|
Adult Glioblastoma
|
0.060 |
Biomarker |
BEFREE |
Our findings suggest that Oct-3/4-expressing glioblastoma cells have the ability to adapt to low-oxygen environments within tumor masses by promoting tumor angiogenesis through AKT-HIF1 pathway.
|
25348671 |
2015 |
|
POU5F1P3
|
Adult Glioblastoma
|
0.060 |
GeneticVariation |
BEFREE |
Gene expression profiles of three glioma stem cell line samples, three normal astrocyte samples, three astrocyte overexpressing 4 iPSC-inducing and oncogenic factors (myc(T58A), OCT-4, p53DD, and H-Ras(G12V)) samples, three astrocyte overexpressing 7 iPSC-inducing and oncogenic factors (OCT4, H-Ras(G12V), myc(T58A), p53DD, cyclin D1, CDK4(RC24) and hTERT) samples and three glioblastoma cell line samples were downloaded from the ArrayExpress database (accession: E-MTAB-4771).
|
28952134 |
2017 |
|
POU5F1P3
|
Adult Glioblastoma
|
0.060 |
Biomarker |
BEFREE |
The involvement of Oct-3/4 in drug resistance of glioblastoma cells was assessed by lactate dehydrogenase assay, efflux assay of an anticancer drug, poly ADP-ribose polymerase cleavage, and in vivo xenograft experiments.
|
25644290 |
2015 |
|
POU5F1P3
|
Adult Liver Carcinoma
|
0.030 |
Biomarker |
BEFREE |
Positive correlation of Oct4 and ABCG2 to chemotherapeutic resistance in CD90(+)CD133(+) liver cancer stem cells.
|
23438193 |
2013 |
|
POU5F1P3
|
Adult Liver Carcinoma
|
0.030 |
AlteredExpression |
BEFREE |
Increased expression of OCT4 and c-JUN was detected in the early stage of human liver cancer.
|
27341307 |
2016 |
|
POU5F1P3
|
Adult Liver Carcinoma
|
0.030 |
Biomarker |
BEFREE |
Though embryonic liver fodrin (ELF) is a pro-differentiation protein, it was expressed in the CD13 positive liver cancer stem cells along with stem cell markers such as Oct-4 and STAT3.
|
29630108 |
2018 |
|
POU5F1P3
|
Adult Lymphoma
|
0.010 |
AlteredExpression |
BEFREE |
In irradiation-resistant p53-mutated lymphoma cell-lines (Namalwa and WI-L2-NS) but not sensitive p53 wild-type counterparts (TK6), low background expression of OCT4 and NANOG was up-regulated by ionising radiation with protein accumulation evident in ETC as detected by OCT4/DNA flow cytometry and immunofluorescence (IF).
|
20457152 |
2010 |