|
POU5F1P3
|
Lupus Erythematosus, Systemic
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the OTF3 gene does not appear to be associated with SLE in the Spanish population.
|
8563733 |
1995 |
|
POU5F1P3
|
Choriocarcinoma
|
0.030 |
Biomarker |
BEFREE |
Here we report that Oct-3/4 strongly inhibits the hCGbeta subunit (hCGbeta) promoter in JAr choriocarcinoma cells.
|
8663260 |
1996 |
|
POU5F1P3
|
Carcinogenesis
|
0.100 |
AlteredExpression |
BEFREE |
As OCT3 expression was detected only in the breast cancerous cells, this embryonic transcription factor could play an important role in mammary gland carcinogenesis.
|
10077160 |
1999 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
From this new knowledge, new markers, eg, FGF4, CD30, and OCT-4, of embryonal carcinoma cells are identifying alternative ways of identifying poor risk tumors and leading to renewed interest in study of histopathology of these tumors.
|
10328600 |
1999 |
|
POU5F1P3
|
Psoriasis
|
0.010 |
GeneticVariation |
BEFREE |
The OTF3 gene polymorphism confers susceptibility to psoriasis independent of the association of HLA-Cw*0602.
|
11069619 |
2000 |
|
POU5F1P3
|
Germ cell tumor
|
0.100 |
Biomarker |
BEFREE |
POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors.
|
12727846 |
2003 |
|
POU5F1P3
|
Malignant neoplasm of breast
|
0.100 |
GeneticVariation |
BEFREE |
Although another POU protein Brn-3 has been shown to be a repressor for BRCA1 (breast-cancer susceptibility gene 1), OCT3 does not repress human or mouse BRCA1/Brca-1 promoters.
|
12841847 |
2003 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
We have demonstrated previously that human breast cancer cells regain the ability to express OCT3 mRNA [Jin, Branch, Zhang, Qi, Youngson and Goss (1999) Int.J.Cancer 81, 104-112].
|
12841847 |
2003 |
|
POU5F1P3
|
Carcinogenesis
|
0.100 |
AlteredExpression |
BEFREE |
These observations indicate that OCT3 protein is selectively expressed in human breast cancer cells, and its expression may be implicated in mammary gland tumorigenesis via up-regulating FGF-4 expression.
|
12841847 |
2003 |
|
POU5F1P3
|
Breast Carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
Although another POU protein Brn-3 has been shown to be a repressor for BRCA1 (breast-cancer susceptibility gene 1), OCT3 does not repress human or mouse BRCA1/Brca-1 promoters.
|
12841847 |
2003 |
|
POU5F1P3
|
Primary malignant neoplasm
|
0.100 |
AlteredExpression |
BEFREE |
We have demonstrated previously that human breast cancer cells regain the ability to express OCT3 mRNA [Jin, Branch, Zhang, Qi, Youngson and Goss (1999) Int.J.Cancer 81, 104-112].
|
12841847 |
2003 |
|
POU5F1P3
|
Germ cell tumor
|
0.100 |
Biomarker |
BEFREE |
In this issue of Cancer Cell, Gidekel et al. demonstrate that Oct-4, a member of the POU class of homeobox genes, is a critical player in the genesis of testicular germ cell tumors.
|
14667497 |
2003 |
|
POU5F1P3
|
Gonadoblastoma
|
0.040 |
AlteredExpression |
BEFREE |
Visibly neoplastic gonadoblastoma and carcinoma in situ (CIS) expressed abundant OCT-3/4 regardless of the age.
|
15105401 |
2004 |
|
POU5F1P3
|
Testicular dysgenesis syndrome
|
0.010 |
AlteredExpression |
BEFREE |
The ontogeny of expression of OCT-3/4 was studied in 74 specimens of normal human gonads during development and in 58 samples of gonads from cases with testicular dysgenesis syndrome (TDS), including disorders of sex differentiation and malignant changes.
|
15105401 |
2004 |
|
POU5F1P3
|
Icterus
|
0.010 |
Biomarker |
BEFREE |
On Oct 3 the patient presenting with general fatigue, nausea and jaundice was admitted to our hospital.
|
15162553 |
2004 |
|
POU5F1P3
|
Teratoma
|
0.080 |
AlteredExpression |
BEFREE |
Furthermore, the feeder-free human embryonic stem cell cultures express the transcription factor Oct-4, alkaline phosphatase, and cell surface markers SSEA-3, SSEA-4, Tra 1-60, Tra 1-81, and formed teratomas in severe combined immunodeficient mice.
|
15965986 |
2005 |
|
POU5F1P3
|
Immunologic Deficiency Syndromes
|
0.020 |
AlteredExpression |
BEFREE |
Furthermore, the feeder-free human embryonic stem cell cultures express the transcription factor Oct-4, alkaline phosphatase, and cell surface markers SSEA-3, SSEA-4, Tra 1-60, Tra 1-81, and formed teratomas in severe combined immunodeficient mice.
|
15965986 |
2005 |
|
POU5F1P3
|
Malignant Testicular Germ Cell Tumor
|
0.030 |
AlteredExpression |
BEFREE |
We provide evidence for the fetal origin of testicular cancer as we detected strong expression of NANOG in fetal gonocytes up to gestational week 20, with subsequent down-regulation occurring earlier than for OCT-4.
|
15982323 |
2005 |
|
POU5F1P3
|
Malignant neoplasm of testis
|
0.020 |
AlteredExpression |
BEFREE |
We provide evidence for the fetal origin of testicular cancer as we detected strong expression of NANOG in fetal gonocytes up to gestational week 20, with subsequent down-regulation occurring earlier than for OCT-4.
|
15982323 |
2005 |
|
POU5F1P3
|
Seminoma
|
0.060 |
Biomarker |
BEFREE |
At the protein level, expression of the immunohistochemical markers cytokeratins (pan-cytokeratin staining), placental-like alkaline phosphatase, anti-cytokeratin clone 5.2, CD30, anion exchanger 1/3, junction plakoglobulin (JUP), and POU domain, class 5, transcription factor 1 (octomer-binding transcription factor 3/4) was significantly different between seminomas and embryonal tumors.
|
16115909 |
2005 |
|
POU5F1P3
|
Embryonal Neoplasm
|
0.030 |
Biomarker |
BEFREE |
At the protein level, expression of the immunohistochemical markers cytokeratins (pan-cytokeratin staining), placental-like alkaline phosphatase, anti-cytokeratin clone 5.2, CD30, anion exchanger 1/3, junction plakoglobulin (JUP), and POU domain, class 5, transcription factor 1 (octomer-binding transcription factor 3/4) was significantly different between seminomas and embryonal tumors.
|
16115909 |
2005 |
|
POU5F1P3
|
Carcinogenesis
|
0.100 |
AlteredExpression |
BEFREE |
Our results suggest that pseudogenes Oct4-pg5 and Oct4-pg1 may be involved in the regulation of Oct4 gene activity thus might be pertinent to carcinogenesis.
|
16229821 |
2005 |
|
POU5F1P3
|
Germ cell tumor
|
0.100 |
Biomarker |
BEFREE |
The abundance of factors associated with pluripotency (NANOG and OCT-3/4) and undifferentiated state (AP-2gamma) may explain the remarkable pluripotency of germ cell neoplasms, which are capable of differentiating to various somatic tissue components of teratomas.
|
16540528 |
2006 |
|
POU5F1P3
|
Teratoma
|
0.080 |
Biomarker |
BEFREE |
The abundance of factors associated with pluripotency (NANOG and OCT-3/4) and undifferentiated state (AP-2gamma) may explain the remarkable pluripotency of germ cell neoplasms, which are capable of differentiating to various somatic tissue components of teratomas.
|
16540528 |
2006 |
|
POU5F1P3
|
Embryonal Carcinoma
|
0.100 |
AlteredExpression |
LHGDN |
We hypothesize that in refractory TGCTs the original tumor stem cell population of Oct-3/4-positive, cisplatin-sensitive EC cells could be replaced by an Oct-3/4-negative, resistant population in a selection process.
|
16557044 |
2006 |