×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.
19286555 2009
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.
15590663 2005
×
Entrez Id: 1636
Gene Symbol: ACE
ACE
Alzheimer's Disease
0.900
Biomarker
GENOMICS_ENGLAND
×
Entrez Id: 1636
Gene Symbol: ACE
ACE
Alzheimer's Disease
0.900
Biomarker
CTD_human
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.
30820047 2019
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
UNIPROT
The only specific molecular defects that cause Alzheimer's disease which have been identified so far are missense mutations in the gene encoding the beta-amyloid precursor protein (beta-APP ) in certain families with an autosomal dominant form of the disease (familial Alzheimer's disease, or FAD).
1465129 1992
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
This study was designed to explore the protective effect of NTR1 on an APP /PS1 double-transgenic mouse model of AD and investigate the possible mechanism.
25714973 2015
×
Entrez Id: 1636
Gene Symbol: ACE
ACE
Alzheimer's Disease
0.900
Biomarker
CTD_human
Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population.10643899 1999
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
UNIPROT
Mis-sense mutation Val----Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease.
1678058 1991
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
UNIPROT
Here, we describe an aggressive form of AD caused by a novel missense mutation in APP (T714I ) directly involving gamma-secretase cleavages of APP .
11063718 2000
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Two proteins related to neurodegenerative diseases have been described as copper binding proteins: the amyloid precursor protein (APP ), a protein related to Alzheimer's disease , and the Prion protein (PrP), related to Creutzfeldt-Jakob disease.
12572668 2003
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
UNIPROT
Characterization of amyloid fibril beta-peptide in familial Alzheimer's disease with APP717 mutations.
8267572 1993
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease.
16325427 2006
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
UNIPROT
A system for studying the effect(s) of familial Alzheimer disease mutations on the processing of the beta-amyloid peptide precursor.
8476439 1993
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Abeta peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer's disease.
16969627 2007
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
UNIPROT
Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43).
8886002 1996
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
APP expression, distribution and accumulation are altered by aluminum in a rodent model for Alzheimer's disease .19818510 2009
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
UNIPROT
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid.
1302033 1992
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Identification of the key molecules involved in chronic copper exposure-aggravated memory impairment in transgenic mice of Alzheimer's disease using proteomic analysis.
25352456 2015
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
UNIPROT
Clinical characteristics in a kindred with early-onset Alzheimer's disease and their linkage to a G-->T change at position 2149 of the amyloid precursor protein gene.
8290042 1994
×
Entrez Id: 1636
Gene Symbol: ACE
ACE
Alzheimer's Disease
0.900
Biomarker
CTD_human
Alzheimer disease risk and genetic variation in ACE: a meta-analysis.
14872014 2004
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Hypothesis for a common basis for neuroprotection in glaucoma and Alzheimer's disease: anti-apoptosis by alpha-2-adrenergic receptor activation.
12852432 2003
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
12192006 2002
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
UNIPROT
We have identified another family, F19, in which we have detected linkage between the beta-amyloid precursor protein gene and Alzheimer's disease .
1944558 1991
×
Entrez Id: 1636
Gene Symbol: ACE
ACE
Alzheimer's Disease
0.900
Biomarker
GENOMICS_ENGLAND
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Peroxisomal proliferation protects from beta-amyloid neurodegeneration.
16204253 2005