×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.
19286555
2009
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.
15590663
2005
×
Entrez Id:
1636
Gene Symbol:
ACE
ACE
Alzheimer's Disease
0.900
Biomarker
CTD_human
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.
30820047
2019
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
This study was designed to explore the protective effect of NTR1 on an APP /PS1 double-transgenic mouse model of AD and investigate the possible mechanism.
25714973
2015
×
Entrez Id:
1636
Gene Symbol:
ACE
ACE
Alzheimer's Disease
0.900
Biomarker
CTD_human
Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population.
10643899
1999
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Two proteins related to neurodegenerative diseases have been described as copper binding proteins: the amyloid precursor protein (APP ), a protein related to Alzheimer's disease , and the Prion protein (PrP), related to Creutzfeldt-Jakob disease.
12572668
2003
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease.
16325427
2006
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Abeta peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer's disease.
16969627
2007
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
APP expression, distribution and accumulation are altered by aluminum in a rodent model for Alzheimer's disease .
19818510
2009
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Identification of the key molecules involved in chronic copper exposure-aggravated memory impairment in transgenic mice of Alzheimer's disease using proteomic analysis.
25352456
2015
×
Entrez Id:
1636
Gene Symbol:
ACE
ACE
Alzheimer's Disease
0.900
Biomarker
CTD_human
Alzheimer disease risk and genetic variation in ACE: a meta-analysis.
14872014
2004
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Hypothesis for a common basis for neuroprotection in glaucoma and Alzheimer's disease: anti-apoptosis by alpha-2-adrenergic receptor activation.
12852432
2003
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
12192006
2002
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Peroxisomal proliferation protects from beta-amyloid neurodegeneration.
16204253
2005
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.
1671712
1991
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease-like symptoms.
23827522
2013
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Agonists of peroxisome proliferator-activated receptor-gamma attenuate the Abeta-mediated impairment of LTP in the hippocampus in vitro.
15993441
2005
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
High performance plasma amyloid-β biomarkers for Alzheimer's disease.
29420472
2018
×
Entrez Id:
1636
Gene Symbol:
ACE
ACE
Alzheimer's Disease
0.900
Biomarker
CTD_human
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database.
17192785
2007
×
Entrez Id:
1636
Gene Symbol:
ACE
ACE
Alzheimer's Disease
0.900
Biomarker
CTD_human
Variation in DCP1 , encoding ACE , is associated with susceptibility to Alzheimer disease .
9916793
1999
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Here we first reported the differential effects of AD -related metal ions at subtoxic concentrations on the transcription levels of APP and BACE1 in PC12 cells.
18583042
2008
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Amyloid-beta peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's disease.
16492752
2006
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease.
28448946
2017
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Mis-sense mutation Val----Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease.
1678058
1991
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers.
30320580
2018