×
Entrez Id: 1636
Gene Symbol: ACE
ACE
Alzheimer's Disease
0.900
Biomarker
GENOMICS_ENGLAND
×
Entrez Id: 1636
Gene Symbol: ACE
ACE
Alzheimer's Disease
0.900
Biomarker
GENOMICS_ENGLAND
×
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
Alzheimer's Disease
0.700
Biomarker
GENOMICS_ENGLAND
×
Entrez Id: 3077
Gene Symbol: HFE
HFE
Alzheimer's Disease
0.700
Biomarker
GENOMICS_ENGLAND
×
Entrez Id: 3077
Gene Symbol: HFE
HFE
Alzheimer's Disease
0.700
Biomarker
GENOMICS_ENGLAND
×
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
Alzheimer's Disease
0.680
Biomarker
CTD_human
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
UNIPROT
Mis-sense mutation Val----Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease.
1678058 1991
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
UNIPROT
We have identified another family, F19, in which we have detected linkage between the beta-amyloid precursor protein gene and Alzheimer's disease .
1944558 1991
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.
1671712 1991
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
UNIPROT
Direct sequencing of DNA from a family with autopsy-proven Alzheimer's disease revealed a single amino acid substitution (Phe for Val) in the transmembrane domain of the amyloid precursor protein .
1925564 1991
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
UNIPROT
These results suggest that the Val----Ile change in the APP causes AD , regardless of ethnic background.
1908231 1991
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Mis-sense mutation Val----Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease.
1678058 1991
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
UNIPROT
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.
1671712 1991
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
UNIPROT
The only specific molecular defects that cause Alzheimer's disease which have been identified so far are missense mutations in the gene encoding the beta-amyloid precursor protein (beta-APP ) in certain families with an autosomal dominant form of the disease (familial Alzheimer's disease, or FAD).
1465129 1992
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
UNIPROT
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid.
1302033 1992
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
CTD_human
Vitamin E protects nerve cells from amyloid beta protein toxicity.
1497677 1992
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
UNIPROT
Previous studies have identified three mutations at APP codon 717 which are pathogenic for Alzheimer disease (AD ).
1415269 1992
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
UNIPROT
Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.
1303239 1992
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
UNIPROT
More missense in amyloid gene.
1303275 1992
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
UNIPROT
Characterization of amyloid fibril beta-peptide in familial Alzheimer's disease with APP717 mutations.
8267572 1993
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
UNIPROT
A system for studying the effect(s) of familial Alzheimer disease mutations on the processing of the beta-amyloid peptide precursor.
8476439 1993
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
Biomarker
CTD_human
Thus APOE -epsilon 4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE -epsilon 4 was virtually sufficient to cause AD by age 80.
8346443 1993
×
Entrez Id: 2147
Gene Symbol: F2
F2
Alzheimer's Disease
0.330
Biomarker
CTD_human
Non-age related differences in thrombin responses by platelets from male patients with advanced Alzheimer's disease.
8333868 1993
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
UNIPROT
Clinical characteristics in a kindred with early-onset Alzheimer's disease and their linkage to a G-->T change at position 2149 of the amyloid precursor protein gene.
8290042 1994
×
Entrez Id: 4129
Gene Symbol: MAOB
MAOB
Alzheimer's Disease
0.400
Biomarker
CTD_human
The up-regulation of monoamine oxidase B in plaque-associated astrocytes in Alzheimer's disease --in analogy to its proposed role in neurodegenerative disorders such as Parkinson's disease--might, indirectly, be a potential source of cytotoxic free radicals.
7816197 1994