×
Entrez Id: 2875
Gene Symbol: GPT
GPT
Drug-Induced Liver Disease
0.400
Biomarker
CTD_human
Nephrotoxic and hepatotoxic effects of triclosan and chlorhexidine in rats.
145039 1977
×
Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2
Drug-Induced Liver Disease
0.300
Biomarker
CTD_human
A phase I study of recombinant human interferon-alpha 2a or human lymphoblastoid interferon-alpha n1 and concomitant zidovudine in patients with AIDS-related Kaposi's sarcoma.
1670585 1991
×
Entrez Id: 3552
Gene Symbol: IL1A
IL1A
Drug-Induced Liver Disease
0.320
Therapeutic
CTD_human
The effect of interleukin 1 alpha on acetaminophen-induced hepatotoxicity.
8218930 1993
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Drug-Induced Liver Disease
0.350
Biomarker
CTD_human
Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6.
7532385 1995
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Drug-Induced Liver Disease
0.350
Therapeutic
CTD_human
Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6.
7532385 1995
×
Entrez Id: 3569
Gene Symbol: IL6
IL6
Drug-Induced Liver Disease
0.330
Therapeutic
CTD_human
Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6.
7532385 1995
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Drug-Induced Liver Disease
0.350
Biomarker
CTD_human
Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure.
9696492 1998
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Drug-Induced Liver Disease
0.350
Therapeutic
CTD_human
Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure.
9696492 1998
×
Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
Drug-Induced Liver Disease
0.310
Therapeutic
CTD_human
IFN-gamma-inducible protein-10 (CXCL10) is hepatoprotective during acute liver injury through the induction of CXCR2 on hepatocytes.
11739529 2001
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Drug-Induced Liver Disease
0.310
Therapeutic
CTD_human
These findings suggest that COX-2 -derived mediators serve an important hepato-protective function and that COX inhibition may contribute to the risk of drug-induced liver injury , possibly through both nonimmunological and immunological pathways.
11743745 2001
×
Entrez Id: 3589
Gene Symbol: IL11
IL11
Drug-Induced Liver Disease
0.300
Therapeutic
CTD_human
Protective effect of rhIL-11 in a murine model of acetaminophen-induced hepatotoxicity.
11421492 2001
×
Entrez Id: 10
Gene Symbol: NAT2
NAT2
Drug-Induced Liver Disease
0.400
Biomarker
CTD_human
Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis.
11915035 2002
×
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Drug-Induced Liver Disease
0.300
Biomarker
CTD_human
A pivotal involvement of IFN-gamma in the pathogenesis of acetaminophen-induced acute liver injury.
12153990 2002
×
Entrez Id: 6649
Gene Symbol: SOD3
SOD3
Drug-Induced Liver Disease
0.300
Therapeutic
CTD_human
EC-SOD gene therapy reduces paracetamol-induced liver damage in mice.
11529661 2002
×
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
Drug-Induced Liver Disease
0.400
Biomarker
CTD_human
Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis.
12668988 2003
×
Entrez Id: 1557
Gene Symbol: CYP2C19
CYP2C19
Drug-Induced Liver Disease
0.320
Biomarker
CTD_human
Association of troglitazone-induced liver injury with mutation of the cytochrome P450 2C19 gene.
12963435 2003
×
Entrez Id: 6652
Gene Symbol: SORD
SORD
Drug-Induced Liver Disease
0.300
Biomarker
CTD_human
Induction of hepatic heme oxygenase-1 by diclofenac in rodents: role of oxidative stress and cytochrome P-450 activity.
12763371 2003
×
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
Drug-Induced Liver Disease
0.300
Biomarker
CTD_human
[Functional analysis of drug metabolizing enzymes using gene knockout animals].
12875239 2003
×
Entrez Id: 1559
Gene Symbol: CYP2C9
CYP2C9
Drug-Induced Liver Disease
0.320
Biomarker
CTD_human
Leflunomide-induced acute hepatitis.
14971821 2004
×
Entrez Id: 9970
Gene Symbol: NR1I3
NR1I3
Drug-Induced Liver Disease
0.320
Therapeutic
CTD_human
A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification.
14742670 2004
×
Entrez Id: 9970
Gene Symbol: NR1I3
NR1I3
Drug-Induced Liver Disease
0.320
Biomarker
CTD_human
A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification.
14742670 2004
×
Entrez Id: 686
Gene Symbol: BTD
BTD
Drug-Induced Liver Disease
0.300
Biomarker
CTD_human
Increased plasma biotinidase activity in rats with paracetamol-induced acute liver injury.
15469856 2004
×
Entrez Id: 50616
Gene Symbol: IL22
IL22
Drug-Induced Liver Disease
0.300
Therapeutic
CTD_human
Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation.
15122762 2004
×
Entrez Id: 50616
Gene Symbol: IL22
IL22
Drug-Induced Liver Disease
0.300
Therapeutic
CTD_human
Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3.
16212920 2004
×
Entrez Id: 3569
Gene Symbol: IL6
IL6
Drug-Induced Liver Disease
0.330
Therapeutic
CTD_human
Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression.
15763341 2005