|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
These results show a significant association of the homozygous HLA-DRB1*07 genotype with UC and CD and of several HLA DR/DQ alleles and haplotypes with the clinical phenotypes of these diseases in Tunisian patients.
|
22224635 |
2012 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DRB1(*)0103 is associated with susceptibility to ulcerative colitis, and IKBL+738(C) marks a propensity to extensive and more severe disease.
|
11113070 |
2000 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
Two HLA-DRB1 causal alleles are shared with adult onset UC, while at least 2 signals are unique to pediatric UC.
|
29562276 |
2018 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
This study suggests that HLA-DRB1 alleles were associated with the clinical course of disease and steroid dependence in UC patients.
|
19674023 |
2010 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
We observed a strong negative association between HLA-DRB1 alleles that encode lysine at position 71 in their beta-chain and susceptibility to ulcerative colitis.
|
10573382 |
1999 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
The rare HLA-DRB1*0103 allele was found to associate with UC (P = 0.008), and the TNFRSF1A A36G variant was associated with familial UC (P = 0.007).
|
18338763 |
2008 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
Eighty Mexican mestizo patients suffering from UC and 99 ethnically matched unrelated healthy controls were genotyped for two TNF-alpha polymorphisms located in the promoter region (positions -308, -238) by polymerase chain reaction (PCR) and amplification refractory mutation system (ARMS) as well as high resolution DNA typing for HLA-DRB1 alleles were performed.
|
15325795 |
2004 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
TNF2 and HLA-DRB1*15 alleles were associated with ANCA-positive UC in the investigated population.
|
10563674 |
1999 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
In Han patients with UC (n = 53), HLA-DRB1 *03, *13 allele frequencies were lower than in healthy controls (n = 161), but not statistically significant, and HLA-DRB1*04*11*14 allele frequencies were higher than in healthy controls, but without statistical significance.
|
23674880 |
2013 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
The frequency of the DRB1*13 allele was decreased in patients with UC (15% versus 28% in controls; P = 0.04; OR = 0.5).
|
9218841 |
1997 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
These observations suggest that the presence of Gly-86 in the HLA beta-chain and surrounding amino acid sequence of HLA-DRB1*1502 is strongly associated with susceptibility to UC.
|
7720475 |
1995 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DRB1 alleles showed no strong association with UC, and no HLA-DRB1 alleles or genotypes were strongly associated with clinical subgroups of UC in Chinese patients.
|
16426241 |
2006 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
In the association study the rare DRB1*103 (8.3% vs 3.2% in controls) and DRB1*12 (8.6% vs 2.1% in controls) alleles were associated with ulcerative colitis (p = 0.0074, chi2 = 7.22, odds ratio OR = 2.9 [95% CI 1.3-6.4] and p = 0.0056, chi2 = 12.63, OR = 4.33 [1.8-11.0] respectively).
|
8622450 |
1996 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
The most implicated gene is HLA-DRB1, with HLA-DRB1*03:01 the most associated risk allele in both Crohn's disease and ulcerative colitis.
|
31518029 |
2019 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
As a whole, after applying Bonferroni's correction for multiple comparisons, no significant association of HLA-DRB1 alleles with Crohn's disease or ulcerative colitis was found.
|
15690658 |
2005 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
Recent studies have suggested that HLA DRB1*0103 and allele 2 of the interleukin 1 receptor antagonist (IL-1RA) gene predict severe and extensive ulcerative colitis, respectively.
|
9178675 |
1997 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
Patients with ulcerative colitis (n = 107) and 200 controls were typed using molecular, DNA-based techniques for HLA-DRB1, DQA1 and DQB1 alleles.
|
9182881 |
1997 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
Haplotype-based analysis in the major histocompatibility complex region showed that HLA-Cw*1202-B*5201-DRB1*1502 haplotype was significantly associated with increased risk of UC compared with CD (P = 1.1 × 10⁻³³; OR = 6.58), accounting for most of the associations observed in the GWAS.
|
21699788 |
2011 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
We confirmed that the NKX2-3 polymorphism is associated with common susceptibility to IBD and that HLA-DRB1*0450 alleles increase susceptibility to CD but reduce risk for UC while HLA-DRB1*1502 alleles increase susceptibility to UC but reduce CD risk.
|
23942620 |
2014 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
Genetic polymorphisms of the HLA-DRB1*08 and *13 may contribute to the clinical heterogeneity of UC between Uyghur and Han UC patients in China.
|
24597629 |
2014 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
This study provides additional evidence for the role of DRB1 alleles in the susceptibility to UC, and supports the hypothesis that these alleles may determine the severity of the disease.
|
9933456 |
1999 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
Whereas the association with the HLA-DRB1*15 allele has been described in several independent studies for ulcerative colitis, no contribution of HLA alleles to susceptibility in Crohn's disease has yet been shown.
|
8707084 |
1996 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
The HLA-DRB1*1502 allele was significantly more frequent in the Indian UC cohort (29.2%) than controls (17.6%) (P = 0.04) and the allele was absent in the white European cohort.
|
24145928 |
2013 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
We conclude that BTNL2 does not contribute to the susceptibility to Japanese CD but is associated with Japanese UC because of the strong LD with HLA-DRB1*1502.
|
17610417 |
2007 |