|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
These results show a significant association of the homozygous HLA-DRB1*07 genotype with UC and CD and of several HLA DR/DQ alleles and haplotypes with the clinical phenotypes of these diseases in Tunisian patients.
|
22224635 |
2012 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
The unexpected finding of a decreased frequency of HLA-DRB1*1601 in ulcerative colitis should be further investigated.
|
7835583 |
1995 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
Data on perinuclear ANCA (pANCA) and HLA-DRB1 were available from 274 ulcerative colitis (UC) patients without known liver disease.
|
27558072 |
2017 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
DRB1*1502 or DRw11 have a probability of being closely related to the intractability of UC.
|
7942717 |
1994 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DRB1(*)0103 is associated with susceptibility to ulcerative colitis, and IKBL+738(C) marks a propensity to extensive and more severe disease.
|
11113070 |
2000 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
Genomic DNAs were obtained from a cohort of n = 383 subjects recruited as part of an Ulcerative Colitis study and analyzed for HLA-DRB1.
|
23555798 |
2013 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
These results extended the reported positive association of DRB1*1502 with UC to another population and supported the genetic susceptibility associated with HLA genes for disease development.
|
9777329 |
1998 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
Two HLA-DRB1 causal alleles are shared with adult onset UC, while at least 2 signals are unique to pediatric UC.
|
29562276 |
2018 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
This study suggests that HLA-DRB1 alleles were associated with the clinical course of disease and steroid dependence in UC patients.
|
19674023 |
2010 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
We observed a strong negative association between HLA-DRB1 alleles that encode lysine at position 71 in their beta-chain and susceptibility to ulcerative colitis.
|
10573382 |
1999 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
HLA-DRB1*03 was less frequent in UC patients than in healthy controls (8% vs 28%, PC < 0.03).
|
9115580 |
1996 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
The rare HLA-DRB1*0103 allele was found to associate with UC (P = 0.008), and the TNFRSF1A A36G variant was associated with familial UC (P = 0.007).
|
18338763 |
2008 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
No significant associations were found between any FCRL3 SNP and CD or UC, but the stratification in patients with UC by human leukocyte antigen (HLA) showed a significant increase in heterozygosity at the FCRL3 locus, especially -169 AG (AG vs AA+GG, P= 0.0027, odds ratio = 3.6, 95% confidence interval 1.4-2.9), when HLA-DRB1*0103 carrier patients were compared with HLA-DRB1*0103 noncarriers.
|
17389014 |
2007 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
Eighty Mexican mestizo patients suffering from UC and 99 ethnically matched unrelated healthy controls were genotyped for two TNF-alpha polymorphisms located in the promoter region (positions -308, -238) by polymerase chain reaction (PCR) and amplification refractory mutation system (ARMS) as well as high resolution DNA typing for HLA-DRB1 alleles were performed.
|
15325795 |
2004 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
Results were as follows: 1) the presence of DQB1*0402 (RR=3.90, Pc=0.0001) was positively associated with CD; 2) the presence of DRB1*1502 (RR=4.51, P<1X10(-8)), DRB5*0102 (RR=4.70, Pc<1x10(-8)), DQA1*0103 (RR=3.72, Pc=1x10(-5)), DQB1*06011 (RR=3.78, PC=1x10(-5)), DPA1*0201 (RR=3.23, Pc=0.0001) and DPB1*0901 (RR=4.83, PC<1x10(8)) was positively associated and that of DRB4*0101 (RR=0.20, Pc<1X10(-8)) and DQA1*0302 (RR=0.34, Pc=0.001) negatively associated with UC; 3) haplotype analysis showed a positive association between the presence of DRB1*0410-DQA1*0302-DQB1*0402 and DRB1*0802-DQA1*0401-DQB1*0402 with CD, and a negative association between the presence of DRB1*1502-DQA1*0103-DQB1*06011 and CD, there was no association of DRB1*08032-DQA1*0103-DQB1*06011 with CD; and 4) in UC, a positive association with the presence of DRB1*1502-DQA1*0103-DQB1*06011 was found, but DRB1*08032-DQA1*0103-DQB1*06011 was not associated with it.
|
10323339 |
1999 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
These data demonstrate the association of the HLA DRB1*0103 allele with both Crohn's disease and ulcerative colitis and with large intestine-restricted disease in non-Jewish IBD patients and therefore identify HLA DRB1*0103 as a potentially important contributor to disease susceptibility and to expression of colonic involvement in IBD.
|
12656131 |
2003 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
TNF2 and HLA-DRB1*15 alleles were associated with ANCA-positive UC in the investigated population.
|
10563674 |
1999 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
In Han patients with UC (n = 53), HLA-DRB1 *03, *13 allele frequencies were lower than in healthy controls (n = 161), but not statistically significant, and HLA-DRB1*04*11*14 allele frequencies were higher than in healthy controls, but without statistical significance.
|
23674880 |
2013 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
The frequency of the DRB1*13 allele was decreased in patients with UC (15% versus 28% in controls; P = 0.04; OR = 0.5).
|
9218841 |
1997 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
The allele frequency of HLA-DRB1*09 was significantly higher in patients with UC diagnosed at the age of 40 years or older than in those with UC diagnosed before the age of 40 years (OR=2.31, Pc=0.022).
|
18416774 |
2008 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
A combination association map of Japanese UC using our current and previous studies showed two equal peaks of association on HLA-DRB1 and HLA-B, indicating the possible existence of two casual variants in the HLA region inside and outside the 400 kb block found in UK.
|
19493234 |
2009 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
HLA-B*52 and DRB1*1502 are reported to be strongly associated with UC in Japan.
|
15215890 |
2004 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
DRB1*1502, which was previously shown to be dominant in Japanese patients with UC, was not observed in this case.
|
16437733 |
2005 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
The allele HLA-DRB1*12 was more frequent in patients with ulcerative colitis (p = 0.01).
|
10190246 |
1999 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
These observations suggest that the presence of Gly-86 in the HLA beta-chain and surrounding amino acid sequence of HLA-DRB1*1502 is strongly associated with susceptibility to UC.
|
7720475 |
1995 |