|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
These observations suggest that the presence of Gly-86 in the HLA beta-chain and surrounding amino acid sequence of HLA-DRB1*1502 is strongly associated with susceptibility to UC.
|
7720475 |
1995 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
The unexpected finding of a decreased frequency of HLA-DRB1*1601 in ulcerative colitis should be further investigated.
|
7835583 |
1995 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
DRB1*1502 or DRw11 have a probability of being closely related to the intractability of UC.
|
7942717 |
1994 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
Significant increase was observed in Bw52, DPw9 (DPB1*0901), and DR2 (DRB1*1502) in Japanese patients with UC.
|
8096500 |
1993 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
In the association study the rare DRB1*103 (8.3% vs 3.2% in controls) and DRB1*12 (8.6% vs 2.1% in controls) alleles were associated with ulcerative colitis (p = 0.0074, chi2 = 7.22, odds ratio OR = 2.9 [95% CI 1.3-6.4] and p = 0.0056, chi2 = 12.63, OR = 4.33 [1.8-11.0] respectively).
|
8622450 |
1996 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
Whereas the association with the HLA-DRB1*15 allele has been described in several independent studies for ulcerative colitis, no contribution of HLA alleles to susceptibility in Crohn's disease has yet been shown.
|
8707084 |
1996 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
HLA-DRB1*03 was less frequent in UC patients than in healthy controls (8% vs 28%, PC < 0.03).
|
9115580 |
1996 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
Recent studies have suggested that HLA DRB1*0103 and allele 2 of the interleukin 1 receptor antagonist (IL-1RA) gene predict severe and extensive ulcerative colitis, respectively.
|
9178675 |
1997 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
Patients with ulcerative colitis (n = 107) and 200 controls were typed using molecular, DNA-based techniques for HLA-DRB1, DQA1 and DQB1 alleles.
|
9182881 |
1997 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
The frequency of the DRB1*13 allele was decreased in patients with UC (15% versus 28% in controls; P = 0.04; OR = 0.5).
|
9218841 |
1997 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
These results extended the reported positive association of DRB1*1502 with UC to another population and supported the genetic susceptibility associated with HLA genes for disease development.
|
9777329 |
1998 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
This study provides additional evidence for the role of DRB1 alleles in the susceptibility to UC, and supports the hypothesis that these alleles may determine the severity of the disease.
|
9933456 |
1999 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
The allele HLA-DRB1*12 was more frequent in patients with ulcerative colitis (p = 0.01).
|
10190246 |
1999 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
Results were as follows: 1) the presence of DQB1*0402 (RR=3.90, Pc=0.0001) was positively associated with CD; 2) the presence of DRB1*1502 (RR=4.51, P<1X10(-8)), DRB5*0102 (RR=4.70, Pc<1x10(-8)), DQA1*0103 (RR=3.72, Pc=1x10(-5)), DQB1*06011 (RR=3.78, PC=1x10(-5)), DPA1*0201 (RR=3.23, Pc=0.0001) and DPB1*0901 (RR=4.83, PC<1x10(8)) was positively associated and that of DRB4*0101 (RR=0.20, Pc<1X10(-8)) and DQA1*0302 (RR=0.34, Pc=0.001) negatively associated with UC; 3) haplotype analysis showed a positive association between the presence of DRB1*0410-DQA1*0302-DQB1*0402 and DRB1*0802-DQA1*0401-DQB1*0402 with CD, and a negative association between the presence of DRB1*1502-DQA1*0103-DQB1*06011 and CD, there was no association of DRB1*08032-DQA1*0103-DQB1*06011 with CD; and 4) in UC, a positive association with the presence of DRB1*1502-DQA1*0103-DQB1*06011 was found, but DRB1*08032-DQA1*0103-DQB1*06011 was not associated with it.
|
10323339 |
1999 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
DR2, DR9, and DRB1*0103 were positively associated with ulcerative colitis, and a negative association was found for DR4 and ulcerative colitis.
|
10446108 |
1999 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
TNF2 and HLA-DRB1*15 alleles were associated with ANCA-positive UC in the investigated population.
|
10563674 |
1999 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
We observed a strong negative association between HLA-DRB1 alleles that encode lysine at position 71 in their beta-chain and susceptibility to ulcerative colitis.
|
10573382 |
1999 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
Our previously reported association of DR2 with UC was attributable to DRB1*1502 (OR = 2.6, p = 0.006).
|
10689124 |
2000 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DRB1(*)0103 is associated with susceptibility to ulcerative colitis, and IKBL+738(C) marks a propensity to extensive and more severe disease.
|
11113070 |
2000 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
Previously, we have reported that the DRB1*1502 and DRw11 genes were closely related to the intractability of UC.
|
11993515 |
2002 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
Our data are consistent with those of Japanese studies in that DR2 and DRB1*1502 are positively associated with UC patients.
|
12073071 |
2002 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
These data demonstrate the association of the HLA DRB1*0103 allele with both Crohn's disease and ulcerative colitis and with large intestine-restricted disease in non-Jewish IBD patients and therefore identify HLA DRB1*0103 as a potentially important contributor to disease susceptibility and to expression of colonic involvement in IBD.
|
12656131 |
2003 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
HLA-B*52 and DRB1*1502 are reported to be strongly associated with UC in Japan.
|
15215890 |
2004 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
Eighty Mexican mestizo patients suffering from UC and 99 ethnically matched unrelated healthy controls were genotyped for two TNF-alpha polymorphisms located in the promoter region (positions -308, -238) by polymerase chain reaction (PCR) and amplification refractory mutation system (ARMS) as well as high resolution DNA typing for HLA-DRB1 alleles were performed.
|
15325795 |
2004 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
This appears to be true for both inflammatory bowel diseases as HLA-DRB1*0103 is associated both with colonic Crohn's disease and ulcerative colitis.
|
15626888 |
2004 |