Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C1142110
Disease: Abdominal Compartment Syndrome
Abdominal Compartment Syndrome
0.010 AlteredExpression BEFREE Early Continuous Veno-Venous Hemofiltration Is Effective in Decreasing Intra-Abdominal Pressure and Serum Interleukin-8 Level in Severe Acute Pancreatitis Patients with Abdominal Compartment Syndrome. 29073601

2017

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.010 GeneticVariation BEFREE In the present study, we genotyped three single nucleotide polymorphisms (SNPs) within IL-8 gene (rs4073, rs2227306 and rs1126647) in 229 individuals who attempted suicide with soft suicide methods, 235 suicide victims and 290 individuals without any history of psychiatric disorders or suicide attempt. 30099207

2018

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0000833
Disease: Abscess
Abscess
0.020 AlteredExpression BEFREE Furthermore, IL-8 and TNF-alpha expression and nuclear phosphorylated NF-kappaB p65 expression could be immunohistochemically confirmed in inflamed epithelium with cryptitis or crypt abscess in UC patients. 19369513

2009

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0000833
Disease: Abscess
Abscess
0.020 AlteredExpression BEFREE IL-8 mRNA levels were significantly higher in patients with a histologic score >2 (p = 0.01) and in patients with crypt abscesses (p = 0.01). 10961587

2000

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0000880
Disease: Acanthamoeba Keratitis
Acanthamoeba Keratitis
0.010 AlteredExpression BEFREE IL-8, part of the Toll-like receptor 4 cytokine cascade, was found to be expressed at a detectable level more often in cases of AK than in control CL wearers (P = 0.003) and in higher concentrations in severe cases than in milder forms of the disease (z = -2.35). 28489721

2017

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0000889
Disease: Acanthosis Nigricans
Acanthosis Nigricans
0.010 AlteredExpression BEFREE BMI, fasting insulin (FINS), and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), tumor necrosis factor-α (TNF-α) and total testosterone (TT) were significantly changed in both groups, while interleukin (IL)-6, IL-8 and C-reactive protein were changed significantly only in the AN group. 30724385

2019

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0702166
Disease: Acne
Acne
0.050 AlteredExpression BEFREE As part of the SICS, this study was conducted to evaluate the association between the incidence of acne vulgaris in SM-exposed subjects (20 years after the exposure) and serum levels of proinflammatory cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) in an attempt to better understand the pathogenesis of long-term skin disorders of these individuals. 28193081

2017

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0702166
Disease: Acne
Acne
0.050 AlteredExpression BEFREE CBT-SL5, a bacteriocin from Enterococcus faecalis, suppresses the expression of interleukin-8 induced by Propionibacterium acnes in cultured human keratinocytes. 18667861

2008

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0702166
Disease: Acne
Acne
0.050 AlteredExpression BEFREE The P. acnes CAMP factor and two proinflammatory cytokines (IL-8 and IL-1β) were expressed at higher levels in acne lesions than those in nonlesional skin. 29964032

2018

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0702166
Disease: Acne
Acne
0.050 AlteredExpression BEFREE Our data showed a statistically significant increase in IL-8 levels from acne patients compared with healthy subjects (154.2 ± 52.1 pg/mL in patients vs. 101.6 ± 33.5 pg/mL in controls, p<0.0001). 26547713

2015

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0702166
Disease: Acne
Acne
0.050 Biomarker BEFREE The aim of this research was to assess the antibacterial activity of Lactobacillus salivarius LS03 (DSM 22776) against Propionibacterium acnes and its anti-inflammatory properties by inhibiting P. acnes-induced interleukin-8 (IL-8) release. 29782471

2019

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0001144
Disease: Acne Vulgaris
Acne Vulgaris
0.030 AlteredExpression BEFREE Our data showed a statistically significant increase in IL-8 levels from acne patients compared with healthy subjects (154.2 ± 52.1 pg/mL in patients vs. 101.6 ± 33.5 pg/mL in controls, p<0.0001). 26547713

2015

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0001144
Disease: Acne Vulgaris
Acne Vulgaris
0.030 AlteredExpression BEFREE As part of the SICS, this study was conducted to evaluate the association between the incidence of acne vulgaris in SM-exposed subjects (20 years after the exposure) and serum levels of proinflammatory cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) in an attempt to better understand the pathogenesis of long-term skin disorders of these individuals. 28193081

2017

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0001144
Disease: Acne Vulgaris
Acne Vulgaris
0.030 AlteredExpression BEFREE The P. acnes CAMP factor and two proinflammatory cytokines (IL-8 and IL-1β) were expressed at higher levels in acne lesions than those in nonlesional skin. 29964032

2018

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0271907
Disease: Acquired aplastic anemia
Acquired aplastic anemia
0.010 GeneticVariation BEFREE Interleukin-2 and Interleukin-8 Gene Polymorphisms and Acquired Aplastic Anemia Risk in a Chinese Population. 28268223

2017

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.010 GeneticVariation BEFREE In this study, we showed the effects of IL-8 gene polymorphisms on OIs and symptoms such as sexually transmitted diseases (STDs), tuberculosis (TB), diarrhea, shortness of breath, weight loss, and viral load, in HIV and acquired immunodeficiency syndrome patients. 26985957

2016

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0151332
Disease: Active tuberculosis
Active tuberculosis
0.010 Biomarker BEFREE In healthy household contacts (HHC), all the tested antigens induced significantly higher levels of IFN-γ and Interlukin-8 (IL-8) compared with those in PTB. 26546406

2015

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0701807
Disease: Acute anterior uveitis
Acute anterior uveitis
0.010 Biomarker BEFREE A significant increase in IFNγ, IL8 and IL6 was observed in the AU AqH, which was also significantly higher than that of paired serum. 29763582

2018

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.010 Biomarker BEFREE In contrast, tissue specimens from two patients with acute appendicitis displayed IL-8-expressing cells in the mucosa. 8178948

1994

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0001311
Disease: Acute bronchiolitis
Acute bronchiolitis
0.010 GeneticVariation BEFREE This finding suggests that IL-8 variations may influence the severity of AB in young infants. 27890033

2017

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome
0.080 GeneticVariation BEFREE This meta-analysis suggests that Chinese patients carrying -251A allele of IL-8 may have an increased risk for the development of CAD, especially ACS. 31770200

2019

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome
0.080 Biomarker BEFREE A cohort (84 females/132 males) from our 1996 ACS study population that had EDTA specimens stored (-70 degrees C) was selected and the earliest available specimen was analyzed for 11 biomarkers (IL-6, IL-8, MCP-1, VEGF, L-selectin, P-selectin, E-selectin, ICAM-1, VCAM-1, NT-proBNP, cTnT). 17964560

2008

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome
0.080 Biomarker BEFREE Lung dysfunction, predominantly restrictive pattern, is common in SCA and is associated with previous ACS and alterations in immunological markers, especially serum IL-8 and hs-CRP. 30295174

2018

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome
0.080 Biomarker BEFREE After adjustment for clinical characteristics and Bonferroni correction, IL-8 (HR 1.60; 95% CI [1.18-2.17] per ln (pg/ml), p = 0.002) was borderline associated with MACE and significantly associated with all-cause mortality or ACS (HR 1.75; 95% CI [1.24-2.48] per ln (pg/ml), p = 0.0015). 30218437

2018

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome
0.080 GeneticVariation BEFREE IL-8 -251 A/T polymorphism was associated with increased susceptibility to ACS (P=0.004; odds ratio=1.30; 95% confidence interval: 1.12-1.53). 21763153

2011