<b>Background:</b> Using a secondary data analysis from randomized controlled trials comparing one year of resistance exercise (<i>n</i> = 109) to a placebo control condition (<i>n</i> = 106) in postmenopausal, posttreatment breast cancer survivors, we investigated the influence of resistance training and changes in body composition on markers associated with cancer progression.<b>Methods:</b> Measures included serum levels of insulin, IGF-1, IGFBP1-3, leptin, serum amyloid A (SAA), adiponectin, C-reactive protein (CRP), IL1β, TNFα, IL6, and IL8, and body composition (total, lean and fat mass in kg) by DXA at baseline, 6, and 12 months.
<b>Background:</b> Using a secondary data analysis from randomized controlled trials comparing one year of resistance exercise (<i>n</i> = 109) to a placebo control condition (<i>n</i> = 106) in postmenopausal, posttreatment breast cancer survivors, we investigated the influence of resistance training and changes in body composition on markers associated with cancer progression.<b>Methods:</b> Measures included serum levels of insulin, IGF-1, IGFBP1-3, leptin, serum amyloid A (SAA), adiponectin, C-reactive protein (CRP), IL1β, TNFα, IL6, and IL8, and body composition (total, lean and fat mass in kg) by DXA at baseline, 6, and 12 months.
<b>Background:</b> Using a secondary data analysis from randomized controlled trials comparing one year of resistance exercise (<i>n</i> = 109) to a placebo control condition (<i>n</i> = 106) in postmenopausal, posttreatment breast cancer survivors, we investigated the influence of resistance training and changes in body composition on markers associated with cancer progression.<b>Methods:</b> Measures included serum levels of insulin, IGF-1, IGFBP1-3, leptin, serum amyloid A (SAA), adiponectin, C-reactive protein (CRP), IL1β, TNFα, IL6, and IL8, and body composition (total, lean and fat mass in kg) by DXA at baseline, 6, and 12 months.
<b>Conclusion:</b> This study highlights the significance of GRO-α and IL-8 as the key chemokines in the peritoneal tumor microenvironment and suggests the utility of targeting their receptor CXCR2 as a potential target-based therapy for peritoneal metastases of ovarian cancer.
<b>Conclusion:</b> This study highlights the significance of GRO-α and IL-8 as the key chemokines in the peritoneal tumor microenvironment and suggests the utility of targeting their receptor CXCR2 as a potential target-based therapy for peritoneal metastases of ovarian cancer.
<b>Conclusions:</b> Elevated levels of IL-6 and IL-8 in blood or BAL fluid at the time of bronchoscopy, and rising levels in blood 4 days following bronchoscopy were predictive of mortality in these patients with underlying hematological malignancy who underwent bronchoscopy for suspected mold infection.
<b>Conclusions:</b> These findings highlight the existence of a specific profile of alveolar cytokines, with IL-8 being the dominant discriminator, which might be useful in supporting current diagnostic approaches for IPA.
<i>Akkermansia muciniphila</i> is potential probiotic in that its type strain ATCC BAA-835 has beneficial effects upon obesity and diabetes.However, whether <i>A. muciniphila</i> can improve inflammatory bowel diseases (IBD), which is a form of chronic intestinal dysbiosis, is unknown.Hence, we used an isolated murine <i>A. muciniphila</i> strain (designated 139) and <i>A. muciniphila</i> type strain ATCC, to investigate their anti-inflammatory properties in cell models and in Dextran Sulfate Sodium (DSS)-induced chronic colitis of mice.<i>In vitro</i>, the two <i>A. muciniphila</i> strains exerted similar anti-inflammatory properties as they both reduced IL-8 production by TNF-α-stimulated HT-29 cells.
<i>Akkermansia muciniphila</i> is potential probiotic in that its type strain ATCC BAA-835 has beneficial effects upon obesity and diabetes.However, whether <i>A. muciniphila</i> can improve inflammatory bowel diseases (IBD), which is a form of chronic intestinal dysbiosis, is unknown.Hence, we used an isolated murine <i>A. muciniphila</i> strain (designated 139) and <i>A. muciniphila</i> type strain ATCC, to investigate their anti-inflammatory properties in cell models and in Dextran Sulfate Sodium (DSS)-induced chronic colitis of mice.<i>In vitro</i>, the two <i>A. muciniphila</i> strains exerted similar anti-inflammatory properties as they both reduced IL-8 production by TNF-α-stimulated HT-29 cells.
<i>Akkermansia muciniphila</i> is potential probiotic in that its type strain ATCC BAA-835 has beneficial effects upon obesity and diabetes.However, whether <i>A. muciniphila</i> can improve inflammatory bowel diseases (IBD), which is a form of chronic intestinal dysbiosis, is unknown.Hence, we used an isolated murine <i>A. muciniphila</i> strain (designated 139) and <i>A. muciniphila</i> type strain ATCC, to investigate their anti-inflammatory properties in cell models and in Dextran Sulfate Sodium (DSS)-induced chronic colitis of mice.<i>In vitro</i>, the two <i>A. muciniphila</i> strains exerted similar anti-inflammatory properties as they both reduced IL-8 production by TNF-α-stimulated HT-29 cells.
<i>Akkermansia muciniphila</i> is potential probiotic in that its type strain ATCC BAA-835 has beneficial effects upon obesity and diabetes.However, whether <i>A. muciniphila</i> can improve inflammatory bowel diseases (IBD), which is a form of chronic intestinal dysbiosis, is unknown.Hence, we used an isolated murine <i>A. muciniphila</i> strain (designated 139) and <i>A. muciniphila</i> type strain ATCC, to investigate their anti-inflammatory properties in cell models and in Dextran Sulfate Sodium (DSS)-induced chronic colitis of mice.<i>In vitro</i>, the two <i>A. muciniphila</i> strains exerted similar anti-inflammatory properties as they both reduced IL-8 production by TNF-α-stimulated HT-29 cells.
<i>Akkermansia muciniphila</i> is potential probiotic in that its type strain ATCC BAA-835 has beneficial effects upon obesity and diabetes.However, whether <i>A. muciniphila</i> can improve inflammatory bowel diseases (IBD), which is a form of chronic intestinal dysbiosis, is unknown.Hence, we used an isolated murine <i>A. muciniphila</i> strain (designated 139) and <i>A. muciniphila</i> type strain ATCC, to investigate their anti-inflammatory properties in cell models and in Dextran Sulfate Sodium (DSS)-induced chronic colitis of mice.<i>In vitro</i>, the two <i>A. muciniphila</i> strains exerted similar anti-inflammatory properties as they both reduced IL-8 production by TNF-α-stimulated HT-29 cells.
<i>FOXP3</i> protein expression in neutrophils and the amount of IL-8 protein in the OSCC tumor microenvironment were determined by immunofluorescence analysis.
<i>FOXP3</i> protein expression in neutrophils and the amount of IL-8 protein in the OSCC tumor microenvironment were determined by immunofluorescence analysis.
<i>Helicobacter pylori (H. pylori)</i> infection leads to gastric inflammation, peptic ulcer and gastric carcinoma.<i>H. pylori</i> activates NADPH oxidase and increases reactive oxygen species (ROS), which induce NF-κB activation and IL-8 expression in gastric epithelial cells.
<i>In vitro</i> studies demonstrated that exposure of the apical face of polarized intestinal cell lines to <i>Bacteroides</i> species supernatants significantly reduced production of interleukin 8 (IL-8), suggesting a mechanism whereby changes in the intestinal microbiota could impact inflammation in CF.
<i>Pseudomonas</i> on BAL was associated with positive neutrophil elastase (OR 4.17, 95% CI 2.04-8.53; p<0.001), increased interleukin-8 (p<0.001), increased all baseline PRAGMA computed tomography scores (p<0.001), progression of PRAGMA computed tomography scores (p<0.05) and increased risk of respiratory exacerbations (incidence rate ratio 2.11, 95% CI 1.15-3.87; p=0.017).In children with CF OPSs only marginally change the probability of detecting lower airway <i>Pseudomonas</i> and are not associated with lung disease indices nor exacerbations risk.
<i>Pseudomonas</i> on BAL was associated with positive neutrophil elastase (OR 4.17, 95% CI 2.04-8.53; p<0.001), increased interleukin-8 (p<0.001), increased all baseline PRAGMA computed tomography scores (p<0.001), progression of PRAGMA computed tomography scores (p<0.05) and increased risk of respiratory exacerbations (incidence rate ratio 2.11, 95% CI 1.15-3.87; p=0.017).In children with CF OPSs only marginally change the probability of detecting lower airway <i>Pseudomonas</i> and are not associated with lung disease indices nor exacerbations risk.
(1) GC patients have higher Hp and CagA seroprevalence than matched controls, confirming that CagA-positive Hp infection is associated with higher risk of GC; (2) serum levels of amidated gastrins and their precursor, progastrin, as well as IL-8 are significantly higher, while serum PG-I levels are reduced in intestinal type GC compared to controls, and (3) determination of high serum progastrin, amidated gastrins and IL-8 combined with low serum PG-I may be useful biomarkers of GC.